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People say, oh, Alzheimer's is genetic garbage.

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That genetic component is only 5%.

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So that means 95% of Alzheimer's risk is environmental.

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Air pollution, microplastics, ultra processed food.

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And a paper just came out showing that sweetener consumption

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correlates with dementia.

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And we think we know why.

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And you've not talked about this publicly yet.

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No, let's talk.

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Dr. Robert Lustig is a world leading sugar expert.

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Who's teaching the world how to reclaim their health

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from the industry that profits off your vulnerability?

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73% of the items in the American grocery store are poisoned

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because sugar is hidden in all the foods.

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For instance, there's 262 names for sugar

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and the food industry uses all of them

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because they knew when they had it, you buy more.

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But the problem is that it's providing people with a dopamine

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hit

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and that dopamine is addictive.

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And that's when you actually have a biochemical and medical

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problem.

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And we have data to show that ultra processed food has been

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associated with dementia,

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diabetes, cancer,

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every single mental health disease.

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So the question is how can you buy healthy food

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and not be tempted by the bad stuff?

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So first, if a food has a label, it's a warning label.

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The second thing, if any food has a sugar in the first three

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ingredients,

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it's dessert.

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And then when they go to the store, don't go hungry.

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And what about exercise?

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Well, it doesn't really impact your desire to reach for sugar.

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It has its own metabolic benefits.

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But if you think exercise is going to make you lose weight,

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you are deluded.

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And we've been talking about that.

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So with all of this in mind, if I've got a sugar problem or if

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I've got an addiction problem,

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what is the remedy?

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I will tell you that this is one of the things I did in my

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obesity clinic.

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So the only way you're going to be able to fix the problems,

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just give me 30 seconds of your time.

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Two things I wanted to say.

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The first thing is a huge thank you for listening and tuning

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into the show.

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Week after week means the world's all of us.

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And this really is a dream that we absolutely never had

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and couldn't ever imagine getting to this place.

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But secondly, it's a dream where we feel like we're only just

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getting started.

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And if you enjoy what we do here, please join the 24% of people

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that listen to this podcast regularly

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and follow us on this app.

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Here's a promise I'm going to make to you.

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I'm going to do everything in my power to make this show as

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good as I can now and into the future.

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We're going to deliver the guests that you want me to speak to

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and we're going to continue to keep doing all of the things you

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love about this show.

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Thank you.

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Dr. Robert, good to have you back. Oh, my pleasure.

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I am particularly fascinated by this term, hostage brain.

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I know you're in the early stages of working on a book about

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this subject,

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but for anyone that doesn't understand,

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so when I look at this word, the hostage brain,

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I think of all the times that I've been out of control.

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And when I say out of control, I'm going to let you define it.

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But when I say out of control, I mean, there's so many things I

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want to do

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as it relates to my health, my fitness, other aspects of my

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life,

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whether it's avoiding eating the cookie to a, in a hotel room

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somewhere,

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or other areas of my life where I want to have greater elements

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of control.

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What does, what do you mean by the hostage brain?

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All of us want to be in control, Stephen.

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I mean, it's the nature of humanity.

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We want to be in control.

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We're going to be in control of our lives.

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Unfortunately, many of us want to be in control of everyone

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else's lives

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as we've seen play out on grand stages lately.

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Okay, everyone wants to be in control.

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And the reason we want to be in control is because then we can

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mitigate threat.

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When you're in control, then threat is low because you're in

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control.

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Problem is we're not in control.

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The more in control, the more a specific area of your brain is

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basically

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glumming on.

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And that area of the brain is known as the amygdala.

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The amygdala is your fear center.

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It's also your 24 hour century, but really what the amygdala is

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,

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it's the point guard on your basketball team.

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Okay, so it surveys the entire court, sees the offense and the

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defense,

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and has to make split second decisions.

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Who's going to score?

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Now, a lousy point guard takes all the shots.

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A good point guard passes off to the guy who has the best shot.

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A great point guard is going to be able to figure out if he's

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going to score,

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or if he's going to pass it off to somebody else.

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If you're in control, your level of threat goes down.

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But really, your control is an illusion.

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You really don't have control.

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And the more you try to exert it, the more you realize you're

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not in control.

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And what that does is that generates an enormous amount of

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stress

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and an enormous amount of pain.

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Now, that pain can turn inward, and we call that depression.

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And right now, 29% of Americans are depressed.

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And 4.4% of the entire world is depressed.

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These numbers were infinitesimal a generation ago.

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And they are basically, you know, just pushing up further and

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further.

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And the reason is because of this inappropriate illusion of

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control.

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And it's causing an enormous amount of pain.

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How do you modify that pain?

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How do you basically deal with the psychological pain of lack

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of control

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that you yourself put upon yourself?

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Well, we have loads of ways.

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Cocaine, amphetamine, nicotine, alcohol, sugar, gambling,

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social media,

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internet gaming, pornography, pick your hoism.

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That's dopamine.

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Dopamine basically provides you with a little bit of pleasure

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on top of a whole lot of pain.

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The problem is that dopamine is addictive.

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And so when you apply a set of pleasures to try to deal with

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your pain of lack of control that puts you into a never-ending

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cycle

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of consumption and misery, that's the hostage brain.

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What do I need to understand about dopamine in order to,

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because I think sometimes

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awareness is step one in being able to do something about

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a problem that you might have.

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So what do I need to understand about what dopamine is and what

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it's doing

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in my brain and how it's associated with addiction

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to then be able to do something about it which I consider step

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two?

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So dopamine basically has two functions.

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The first is learning. There's no learning without dopamine.

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Anytime you learn something, whether it's positive or negative,

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it's because there was a dopamine release.

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When you put your hand down on a hot stove when you were three

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years old

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and went, "Oh, I'm never doing that again."

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Okay, that was dopamine that did that.

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Okay, and what it did was it went to your amygdala and it re

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wired it.

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That was a rewiring of your amygdala due to the excitatory

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neurostimulus of that dopamine affecting an area of your brain

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called the basalateral amygdala. Okay, and it laid down and it

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set up a circuit

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and that circuit is still working in you right now.

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Okay, so dopamine is the learning neurotransmitter.

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It can be for negative learning. It can be for positive

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learning either way.

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Dopamine is also when it's going to another area of the brain

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called the nucleus accumbens, which is the reward center.

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That is a stimulus for reward. That is the motivation for

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reward.

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That is in one word for play. Okay, that is the excitement.

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The reason for continuing any given behavior. Okay, you get

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both out of dopamine.

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Okay, and in short, small bursts in the right venue,

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that's how we navigate life. We navigate it through learning,

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and we navigate it through reward. You can't do it without

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dopamine.

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Dopamine is good unless it's bad, and as you know, everything

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in science

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is both good and bad. The problem is chronic overstimulation of

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any neuron

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leads to neuronal cell death. Dopamine is a chronic stimulator,

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and so if you have chronic dopamine being released,

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what's going to happen is you're going to kill the next neuron.

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Now, that neuron doesn't want to die. So it down regulates the

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receptors for dopamine,

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so that it's less likely that one dopamine over here is going

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to find the receptor

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over here to bind to because there are a few of them. So what

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this means is more and more

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for less and less, and we call that phenomenon tolerance, more

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dopamine, more tolerance,

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so the law of diminishing returns. So you get a hit, you get a

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rush,

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it'd be a sugar, alcohol, whatever it might be. Pick your

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pornography, yeah. Pick your poison,

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doesn't matter. You get a rush, receptors go down next time you

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need a bigger hit to get the

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same rush, receptors go down, and then you get a bigger hit and

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a bigger hit until finally,

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you get a huge hit to get nothing. That's called tolerance, and

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then when the neurons actually

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start to die, that's called addiction. So tolerance is the

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start of addiction, and the problem is

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more dopamine, more tolerance, more tolerance, more addiction.

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So people that are getting addicted to unhealthy foods and

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sugars and those kinds of things,

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what's going on in that brain? So at first, the first time they

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taste it, whatever it is,

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whether it's a fruit loop or a candy corn or a frappuccino or

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pick your poison,

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you get this big sugar bomb going off in your head, and you go,

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wow, this is great. I want some

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more of this. I'm going to show you down the whole frappuccino,

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okay. And what you've done is you've

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basically hit your nucleus Cummins with a big slug of dopamine,

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and you go, wow, that was great.

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And then an hour later, it's gone, and then you go, God, I need

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that again.

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So the first time you got it, you liked it. The second time you

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did it, you wanted it,

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and the third time you needed it. So that's the difference

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between liking and wanting and needing,

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okay, because liking we all do, and no one wants to take away

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liking. One thing gets into problems,

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because you can over abuse things. Needing is when you actually

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have a biochemical and medical

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problem. So with all of this in mind, if I've got a sugar

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problem or if I've got an addiction

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problem, I'm addicted to insert poison. What is the remedy?

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Just avoid it for a while,

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and then if that is the remedy, what's going on in my brain? Is

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it fixing itself?

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There are many remedies, okay, and they can all be used in

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conjunction with each other.

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Ultimately, the only thing that's going to work is getting

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those dopamine receptors back up.

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Remember, I told you dopamine down regulates its own receptor.

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The only way you're going to be

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able to fix the problem is for the dopamine receptors to come

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back up. There's a trend going on

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right now at the Silicon Valley you may have heard of called

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dopamine fasting.

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Yeah, you've had the word. Basically, people lock themselves up

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in a hotel room for three weeks.

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Don't take a shower and basically take the TVs out of the room

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and try to commune with

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themselves and with nature with no stimuli, with no external

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stimuli. In order to bring their

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dopamine receptors back up, particularly true of cocaine

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addicts because their dopamine receptors

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are way down because after all, cocaine is a dopamine reuptake

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inhibitor. So it's flooding the

259
00:12:47.880 --> 00:12:51.950
zone with dopamine. Therefore, those receptors are down on the

260
00:12:51.950 --> 00:12:55.480
sewer. Now, do you have to be that

261
00:12:55.480 --> 00:13:00.790
severe? No, of course not. But does it work? Takes three weeks.

262
00:13:00.790 --> 00:13:02.600
You want to do it for three weeks?

263
00:13:03.240 --> 00:13:07.480
Then it works. Other ways, you can wean yourself off. You can

264
00:13:07.480 --> 00:13:11.320
do abstinence. If you can do

265
00:13:11.320 --> 00:13:15.810
abstinence, that's a good idea. Hard to do, especially when it

266
00:13:15.810 --> 00:13:17.800
's staring at you and when it's

267
00:13:17.800 --> 00:13:22.630
available 24/7, 365, like sugar is. It's everywhere. It's on

268
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every street corner.

269
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When I fast or when I do the kids' genetic diet, I lose my

270
00:13:28.890 --> 00:13:31.800
apparent cravings. That's right.

271
00:13:32.920 --> 00:13:37.790
Exactly right. The reason is because no sugar in a ketogenic

272
00:13:37.790 --> 00:13:40.840
diet, so you're basically removing

273
00:13:40.840 --> 00:13:45.400
the offensive stimulus. I was so shocked. I love those cinnamon

274
00:13:45.400 --> 00:13:46.280
roll things. Not that I

275
00:13:46.280 --> 00:13:49.030
probably won every two years, but I love them nonetheless. I'm

276
00:13:49.030 --> 00:13:50.040
like a big admirer, even though we

277
00:13:50.040 --> 00:13:54.210
don't have a relationship anymore. When I did the ketogenic

278
00:13:54.210 --> 00:13:56.520
diet for about us four weeks in,

279
00:13:56.520 --> 00:13:59.800
I'm not having any sugar or carbohydrates, and I walked up to

280
00:13:59.800 --> 00:14:01.960
this concession in Cape Town

281
00:14:01.960 --> 00:14:05.400
with all these amazing cinnamon rolls, like specialists, and I

282
00:14:05.400 --> 00:14:07.400
looked at them. There was zero

283
00:14:07.400 --> 00:14:10.590
parts of my brain that was interested in any of it. The zero

284
00:14:10.590 --> 00:14:11.720
part of my brain, and I was like,

285
00:14:11.720 --> 00:14:15.340
wow, my brain has been rewired or something, just because I've

286
00:14:15.340 --> 00:14:17.080
removed sugar from my diet.

287
00:14:17.080 --> 00:14:24.240
It happens, but it takes a while. It's not something that you

288
00:14:24.240 --> 00:14:25.240
can turn on and off.

289
00:14:26.280 --> 00:14:30.920
It takes a fair amount of time. I will tell you that this is

290
00:14:30.920 --> 00:14:33.640
one of the things I did in my

291
00:14:33.640 --> 00:14:37.980
obesity clinic on a daily basis, was getting people off their

292
00:14:37.980 --> 00:14:39.480
sugar addiction.

293
00:14:39.480 --> 00:14:43.890
Sometimes you have to basically babysit them. You have to work

294
00:14:43.890 --> 00:14:45.800
with them and work with their

295
00:14:45.800 --> 00:14:49.970
parents in order to basically turn over the entire pantry,

296
00:14:49.970 --> 00:14:51.960
because the sugar is hidden in

297
00:14:51.960 --> 00:14:57.620
all the foods. It's the 262 names for sugar, and the food

298
00:14:57.620 --> 00:14:59.000
industry uses all of them.

299
00:14:59.000 --> 00:15:01.940
This is why we are trying to get sugar addiction and ultra-

300
00:15:01.940 --> 00:15:04.280
processed food addiction codified

301
00:15:04.280 --> 00:15:09.940
by the WHO and by the American Psychiatric Association as a bon

302
00:15:09.940 --> 00:15:12.200
afide diagnosis so that we can get

303
00:15:12.200 --> 00:15:16.250
remediation and therapy for people. One of the things that was

304
00:15:16.250 --> 00:15:17.640
one of the most popular parts of

305
00:15:17.640 --> 00:15:20.560
our conversation last time, Robert, was there's a section where

306
00:15:20.560 --> 00:15:22.200
we talked about the different types of

307
00:15:22.200 --> 00:15:25.390
sugar and diet cokes and coke zeros and all these kinds of

308
00:15:25.390 --> 00:15:29.880
things. I can see a couple of

309
00:15:29.880 --> 00:15:33.640
cans on the desk over there where jack is in the darkness that

310
00:15:33.640 --> 00:15:36.520
I can vaguely see, and these

311
00:15:36.520 --> 00:15:39.440
cans of fizzy drink, they all have some kind of sugar

312
00:15:39.440 --> 00:15:41.960
substitute. Are those sugar substitutes

313
00:15:41.960 --> 00:15:47.330
homeness? No, of course not. A paper just came out like three

314
00:15:47.330 --> 00:15:49.720
days ago in annals of neurology,

315
00:15:49.720 --> 00:15:57.290
basically showing that non-nutritive sweetener consumption, so

316
00:15:57.290 --> 00:16:00.440
diet sweetener consumption correlates

317
00:16:00.440 --> 00:16:06.930
with dementia, and we think we know why. Why? Reactive oxygen

318
00:16:06.930 --> 00:16:09.560
species, so oxygen radicals,

319
00:16:10.360 --> 00:16:13.800
little chemicals that are given off from various substances

320
00:16:13.800 --> 00:16:18.200
that cause changes in energy metabolism

321
00:16:18.200 --> 00:16:22.850
in cells and also cause damage in cells. Are oeses reactive

322
00:16:22.850 --> 00:16:25.400
oxygen species? The famous ones

323
00:16:25.400 --> 00:16:31.560
are spartame and suculose. Now, do monk fruit extract, do stev

324
00:16:31.560 --> 00:16:35.240
ia, does allulose, also cause reactive

325
00:16:35.240 --> 00:16:39.290
oxygen species. I very specifically looked for data on those

326
00:16:39.290 --> 00:16:41.080
could not find it, but for

327
00:16:41.080 --> 00:16:45.110
spartame and for suculose, the two biggest ones that are

328
00:16:45.110 --> 00:16:47.320
available today, the ones that are used

329
00:16:47.320 --> 00:16:52.650
in a lot of diet drinks, huge amounts of ROS generation. So

330
00:16:52.650 --> 00:16:56.520
reactive oxygen species generation.

331
00:16:56.520 --> 00:17:02.550
So anything that generates ROS is contributes to dementia. Is

332
00:17:02.550 --> 00:17:04.440
the evidence strong at this stage?

333
00:17:05.240 --> 00:17:08.430
Yeah, it's pretty darn strong. I'm actually giving a talk about

334
00:17:08.430 --> 00:17:09.800
this next week in San Diego.

335
00:17:09.800 --> 00:17:13.850
I heard you've got a new theory on the causes of Alzheimer's

336
00:17:13.850 --> 00:17:15.800
dementia. That's somewhat linked.

337
00:17:15.800 --> 00:17:19.480
Is it? Is it? Yeah. Can you explain that to me? And you've not

338
00:17:19.480 --> 00:17:20.440
talked about this publicly yet.

339
00:17:20.440 --> 00:17:23.530
You've sent a talk about it in a couple of days over here. Let

340
00:17:23.530 --> 00:17:26.440
me take it back a step, okay?

341
00:17:26.440 --> 00:17:31.400
There's this organelle inside our brains called mitochondria.

342
00:17:31.400 --> 00:17:33.320
You've heard of mitochondria.

343
00:17:33.320 --> 00:17:36.020
Yeah, for the, for your audience, mitochondria, the little

344
00:17:36.020 --> 00:17:37.800
energy burning factories inside

345
00:17:37.800 --> 00:17:41.850
each of our cells. What they do is they take food energy and

346
00:17:41.850 --> 00:17:43.640
turn it into the chemical energy

347
00:17:43.640 --> 00:17:47.260
that your cell can actually use to power itself. Okay, and that

348
00:17:47.260 --> 00:17:49.400
chemical energy has a name. It's

349
00:17:49.400 --> 00:17:54.750
called ATP. Now, if you took biology in high school, you've

350
00:17:54.750 --> 00:17:57.640
heard of ATP, adenosine triphosphate,

351
00:17:57.640 --> 00:18:03.300
the energy is in the phosphate bonds. So ATP will give up its

352
00:18:03.300 --> 00:18:05.480
energy and go to ADP,

353
00:18:05.480 --> 00:18:10.600
diphosphate, which will then give up its energy and go to AMP

354
00:18:10.600 --> 00:18:12.840
monophosphate, which will then

355
00:18:12.840 --> 00:18:17.450
finally go to a denosine. And a denosine binds to the adenosine

356
00:18:17.450 --> 00:18:19.560
receptor and makes you go to sleep.

357
00:18:19.560 --> 00:18:23.670
By the way, that's where caffeine works. It blocks the adenos

358
00:18:23.670 --> 00:18:25.960
ine receptor, keeping you awake

359
00:18:25.960 --> 00:18:29.400
so that the adenosine can't bind to the adenosine receptor.

360
00:18:29.400 --> 00:18:34.840
Okay. So that ATP is the currency of the cell.

361
00:18:34.840 --> 00:18:40.840
That's what makes the cell run. Anything that depletes ATP is

362
00:18:40.840 --> 00:18:42.840
going to put the cell at risk.

363
00:18:42.840 --> 00:18:48.280
Okay, because it doesn't have the energy it needs to run. Yeah,

364
00:18:48.280 --> 00:18:49.640
it's gasoline.

365
00:18:49.640 --> 00:18:52.730
It's like gasoline. So what happens when you start running out

366
00:18:52.730 --> 00:18:53.480
of gasoline?

367
00:18:54.200 --> 00:18:58.330
Well, you break down. You'll break down. So brain fog,

368
00:18:58.330 --> 00:19:02.680
difficulty concentrating, irritability,

369
00:19:02.680 --> 00:19:08.400
and ultimately all the way to depression. So the amount of ATP

370
00:19:08.400 --> 00:19:10.520
within any given neuron

371
00:19:10.520 --> 00:19:19.160
is the approximate cause of neuronal dysfunction that we see as

372
00:19:19.160 --> 00:19:21.240
neurocognitive and neurobehavioral

373
00:19:21.240 --> 00:19:27.480
change. Now, how to mitochondria and how to ROSs fit into this

374
00:19:27.480 --> 00:19:31.400
mitochondria make ATP.

375
00:19:31.400 --> 00:19:36.030
But every time they make ATP, they make also make ROSs. There

376
00:19:36.030 --> 00:19:38.600
are 11 steps in mitochondria,

377
00:19:38.600 --> 00:19:43.080
and they all give off ROSs. Now, those ROSs are going to damage

378
00:19:43.080 --> 00:19:45.800
the cell. They have to be gotten

379
00:19:45.800 --> 00:19:51.460
rid of. They're like toxic fumes. They got to be gotten rid of.

380
00:19:51.460 --> 00:19:54.360
And so we have a pathway in each

381
00:19:54.360 --> 00:19:59.420
cell of our body to get rid of the toxic ROSs. Okay. They're

382
00:19:59.420 --> 00:20:04.520
called antioxidants, like glutathione,

383
00:20:04.520 --> 00:20:11.360
vitamin E, vitamin C, host of other flavonoids. Okay. Those

384
00:20:11.360 --> 00:20:14.600
basically quench those reactive oxygen

385
00:20:14.600 --> 00:20:19.800
species. They go to die. If you do that, then the ROSs

386
00:20:19.800 --> 00:20:23.560
basically just get funneled away and all

387
00:20:23.560 --> 00:20:27.060
as well in the cell can keep working. But if for some reason

388
00:20:27.060 --> 00:20:29.720
those antioxidants aren't up to par,

389
00:20:29.720 --> 00:20:33.360
if for instance, you're being eating ultra-processed food and

390
00:20:33.360 --> 00:20:35.560
you can't make your antioxidant

391
00:20:35.560 --> 00:20:40.000
complement, then the ROS's feedback and what happens is the ROS

392
00:20:40.000 --> 00:20:42.360
s are basically telling the cell,

393
00:20:42.360 --> 00:20:48.020
hey, you're shunting too much energy down this pathway because

394
00:20:48.020 --> 00:20:51.400
I can't clear them. So there's too

395
00:20:51.400 --> 00:20:57.060
much stuff. So shut it down. And so what happens is that

396
00:20:57.060 --> 00:21:00.600
instead of funneling the glucose into the

397
00:21:00.600 --> 00:21:04.650
mitochondria to generate more ATP, it diverts it and it goes

398
00:21:04.650 --> 00:21:07.720
off into other directions like glycogen,

399
00:21:07.720 --> 00:21:11.420
which is, and the brain is not good or fat, which is even worse

400
00:21:11.420 --> 00:21:15.320
. And bottom line, your cell is

401
00:21:15.320 --> 00:21:20.570
now not energy-producing, like it used to be. It has now been

402
00:21:20.570 --> 00:21:23.000
reduced in terms of its energy

403
00:21:23.000 --> 00:21:26.870
capacity. What's that going to do? That's going to reduce ATP

404
00:21:26.870 --> 00:21:30.520
generation. Okay. That's step one.

405
00:21:31.560 --> 00:21:37.060
Now step two, there's this stuff called cortisol. Cortisol

406
00:21:37.060 --> 00:21:40.440
comes from stress. Cortisol comes from

407
00:21:40.440 --> 00:21:44.850
sleep deprivation. Cortisol comes from exogenous glucocortic

408
00:21:44.850 --> 00:21:47.240
oids, like steroids being given to people

409
00:21:47.240 --> 00:21:56.410
for autoimmune disease or for other illnesses. That cortisol

410
00:21:56.410 --> 00:22:00.440
causes neurons to increase in

411
00:22:01.560 --> 00:22:06.740
metabolism, it causes them to burn energy faster. Okay. So you

412
00:22:06.740 --> 00:22:09.400
now have an increased ATP utilization.

413
00:22:09.400 --> 00:22:13.190
So you have a decreased ATP generation. Now you have an

414
00:22:13.190 --> 00:22:15.400
increased ATP utilization.

415
00:22:15.400 --> 00:22:21.390
Now you've got an energy crisis inside each cell. Now your ATP

416
00:22:21.390 --> 00:22:23.480
can't keep up with the needs of the

417
00:22:23.480 --> 00:22:28.910
cell. And when that happens, now you've got symptoms, whether

418
00:22:28.910 --> 00:22:31.880
it's brain fog or irritability or

419
00:22:31.880 --> 00:22:37.910
all the way to frank depression. Okay. Now step three, there

420
00:22:37.910 --> 00:22:42.040
are these proteins inside each neuron

421
00:22:42.040 --> 00:22:49.800
called amyloid precursor peptide, ATP. Okay. So normal protein

422
00:22:49.800 --> 00:22:52.760
in all cells. Every cell in your body

423
00:22:52.760 --> 00:22:58.610
has ATP. It needs to stay in solution. And in order for to stay

424
00:22:58.610 --> 00:23:01.640
in solution, energy has to be applied

425
00:23:01.640 --> 00:23:05.450
to it in order to keep it in solution. The minute the ATP and

426
00:23:05.450 --> 00:23:08.120
the cell goes down, they come out of

427
00:23:08.120 --> 00:23:14.030
solution and they start forming aggregates, which we call pl

428
00:23:14.030 --> 00:23:18.760
aques. Yeah. Okay. And those plaques

429
00:23:18.760 --> 00:23:23.880
damage the cell, which then start an inflammatory process

430
00:23:23.880 --> 00:23:29.020
in the cells next door called the microglia in order to clean

431
00:23:29.020 --> 00:23:31.240
up the process. And now you've got

432
00:23:31.240 --> 00:23:34.710
plaques and an inflammation. And now you've got neuronal cell

433
00:23:34.710 --> 00:23:40.360
death. That's dementia. So it starts

434
00:23:41.240 --> 00:23:48.310
with an ATP energy crisis moves through plaque and inflammation

435
00:23:48.310 --> 00:23:50.440
to generate neuronal cell death.

436
00:23:50.440 --> 00:23:55.320
Well, this is problematic to say the least. And by the way,

437
00:23:55.320 --> 00:23:59.570
anything that generates ROSs has been associated with Alzheimer

438
00:23:59.570 --> 00:24:02.280
's, anything that increases ATP

439
00:24:02.280 --> 00:24:07.130
utilization, like stress, glucocorticoids, fever, autoimmune

440
00:24:07.130 --> 00:24:10.840
disease, also increases Alzheimer's.

441
00:24:10.840 --> 00:24:13.410
So anything that increases step one, anything that increases

442
00:24:13.410 --> 00:24:15.880
step two ultimately leads to increased

443
00:24:15.880 --> 00:24:20.300
step three and Alzheimer's. So to simplify this in a couple of

444
00:24:20.300 --> 00:24:21.880
sentences for someone that has

445
00:24:21.880 --> 00:24:25.310
no scientific understanding, and we're going to have to cut a

446
00:24:25.310 --> 00:24:27.320
few corners here scientifically in

447
00:24:27.320 --> 00:24:30.620
order to, to, for them to have a free one to understand it, how

448
00:24:30.620 --> 00:24:32.120
would you give me some sort of

449
00:24:32.120 --> 00:24:35.310
analogy for it? Maybe in the context of, I guess, a petrol

450
00:24:35.310 --> 00:24:37.400
station in a car? Yeah. So I mean, if we're

451
00:24:37.400 --> 00:24:41.530
basically doing petrol, we're talking energy only. Yeah. Okay.

452
00:24:41.530 --> 00:24:46.680
So bottom line, your car runs on petrol.

453
00:24:46.680 --> 00:24:52.360
Okay. The petrol comes in. That's the glucose. And the engine

454
00:24:52.360 --> 00:24:56.760
powers pistons and the pistons

455
00:24:56.760 --> 00:25:02.260
then power and axle, and the axle then powers wheels. And you

456
00:25:02.260 --> 00:25:04.840
go. Yeah. Okay. But there are a lot of

457
00:25:04.840 --> 00:25:08.600
things that have to go right for all of those things to happen.

458
00:25:08.600 --> 00:25:12.920
Like for instance, your energy,

459
00:25:12.920 --> 00:25:17.030
the, the gasoline has to get into the engine in the first place

460
00:25:17.030 --> 00:25:19.400
. What if you have carbon deposits

461
00:25:19.400 --> 00:25:22.590
on your intake manifolds? And if you have a problem with any

462
00:25:22.590 --> 00:25:23.720
one of those steps,

463
00:25:24.600 --> 00:25:29.160
you're going to end up with a jalapien instead of a sports car.

464
00:25:29.160 --> 00:25:30.120
I mean, that's what we're seeing in the

465
00:25:30.120 --> 00:25:32.840
United States over seven million Americans live with Alzheimer

466
00:25:32.840 --> 00:25:34.760
's. And this is expected to double to

467
00:25:34.760 --> 00:25:40.600
almost 13 million in the coming decades. Indeed. Because we

468
00:25:40.600 --> 00:25:43.400
haven't solved the problem.

469
00:25:43.400 --> 00:25:48.770
That's the mechanism. What is, what is the cause? Right. So we

470
00:25:48.770 --> 00:25:52.840
know, we know that the cause is

471
00:25:52.840 --> 00:25:59.580
environmental. Now, people say, Oh, Alzheimer's is genetic

472
00:25:59.580 --> 00:26:03.480
garbage. There is a genetic component to

473
00:26:03.480 --> 00:26:06.850
Alzheimer's. I'm not arguing that there is. Okay. This is thing

474
00:26:06.850 --> 00:26:10.280
called apo E4. And if you have two

475
00:26:10.280 --> 00:26:15.420
copies of apo E4 on your genome, your risk for getting

476
00:26:15.420 --> 00:26:19.080
Alzheimer's is nine times the general population.

477
00:26:19.720 --> 00:26:23.050
That is absolutely true. I don't disagree with that. So apo E4

478
00:26:23.050 --> 00:26:25.640
is not a good thing. I'm not arguing

479
00:26:25.640 --> 00:26:30.020
that. Once upon a time in, you know, evolution, having two

480
00:26:30.020 --> 00:26:33.400
copies of apo E4 was good because it meant

481
00:26:33.400 --> 00:26:36.990
you got fat up your brain pretty fast. But we don't need that

482
00:26:36.990 --> 00:26:38.680
right now. That's kind of a,

483
00:26:38.680 --> 00:26:44.630
an old news kind of a, a, a, of issue. People who have double

484
00:26:44.630 --> 00:26:48.040
doses of apo E4 are at higher risk.

485
00:26:48.040 --> 00:26:50.610
There is absolutely no question about that, but they can

486
00:26:50.610 --> 00:26:53.160
mitigate that risk if they change their diet.

487
00:26:53.160 --> 00:26:59.460
Okay. They can eat a very low fat diet and, and improve their

488
00:26:59.460 --> 00:27:02.120
risk down to the general population.

489
00:27:02.120 --> 00:27:10.120
Okay. Everything else in Alzheimer's is not genetic. By the way

490
00:27:10.120 --> 00:27:12.040
, that genetic component is only

491
00:27:12.040 --> 00:27:18.360
5% of all Alzheimer's. So that means 95% of Alzheimer's risk is

492
00:27:18.360 --> 00:27:20.520
environmental. Now, the question is,

493
00:27:20.520 --> 00:27:25.910
what in the environment? Well, air pollution, ionizing

494
00:27:25.910 --> 00:27:30.040
radiation, microplastics.

495
00:27:30.040 --> 00:27:34.600
Okay. There's nothing you can do about any one of those three.

496
00:27:34.600 --> 00:27:37.160
That's baked into the cake.

497
00:27:38.280 --> 00:27:43.230
You can't do anything about those today. What other things?

498
00:27:43.230 --> 00:27:44.440
Sleep disorder, breathing,

499
00:27:44.440 --> 00:27:53.250
medications, ultra processed food. Okay. What about ultra

500
00:27:53.250 --> 00:27:54.120
processed food?

501
00:27:54.120 --> 00:27:59.180
Frick toes, my favorite, you know, hobby horse, you know, the

502
00:27:59.180 --> 00:28:00.520
sweet molecule and sugar,

503
00:28:01.480 --> 00:28:10.030
low omega threes. So no, you know, fish, eggs, chicken. Lack of

504
00:28:10.030 --> 00:28:11.240
fiber,

505
00:28:11.240 --> 00:28:17.880
because fiber suppresses inflammation, presence of emulsifiers.

506
00:28:17.880 --> 00:28:25.440
Okay. B vitamins, lack of B vitamins, particularly B6, B12 fol

507
00:28:25.440 --> 00:28:25.960
ate.

508
00:28:27.480 --> 00:28:31.850
Okay. Those things are all associated with an increase in

509
00:28:31.850 --> 00:28:34.040
reactive oxygen species.

510
00:28:34.040 --> 00:28:39.240
You can manage those. You can mitigate those.

511
00:28:39.240 --> 00:28:44.310
They're by increasing mitochondrial function, increasing ATP

512
00:28:44.310 --> 00:28:48.120
generation, and preventing that cellular

513
00:28:48.120 --> 00:28:52.430
energy crisis so that you don't end up behind the eight ball,

514
00:28:52.430 --> 00:28:55.000
and you don't lose your neurons.

515
00:28:55.000 --> 00:28:58.760
When people tell me that Alzheimer's is associated with having

516
00:28:58.760 --> 00:29:00.520
a sort of energy crisis in the brain,

517
00:29:00.520 --> 00:29:05.150
I'm increasingly hearing people talk about ketones. It's

518
00:29:05.150 --> 00:29:08.520
remarkable the improvement in cognitive

519
00:29:08.520 --> 00:29:12.330
performance that I feel when I'm fasted or I'm in a ketogenic

520
00:29:12.330 --> 00:29:14.280
diet, whereas if I'm in a,

521
00:29:14.280 --> 00:29:18.890
if I've been eating a lot of carbohydrates or sugar, it's like

522
00:29:18.890 --> 00:29:20.040
my brain is like

523
00:29:20.840 --> 00:29:25.170
like backfiring. Yeah, it's stumbling over itself. I'm not

524
00:29:25.170 --> 00:29:25.720
surprised.

525
00:29:25.720 --> 00:29:30.510
Yeah, the food industry tells you, well, carbohydrates are

526
00:29:30.510 --> 00:29:32.840
energy. Actually, that's not true.

527
00:29:32.840 --> 00:29:37.080
Carbohydrates inhibit energy production. How do you mean?

528
00:29:37.080 --> 00:29:41.500
So there's this thing called a bomb calorimeter, and there's

529
00:29:41.500 --> 00:29:43.160
this thing called a mitochondria.

530
00:29:43.160 --> 00:29:49.000
They're not the same. A bomb calorimeter, you throw food into

531
00:29:49.000 --> 00:29:50.200
the bomb calorimeter,

532
00:29:50.200 --> 00:29:54.250
it explodes and it gives off heat. And there's, you know,

533
00:29:54.250 --> 00:29:56.040
captures the heat, measures the heat.

534
00:29:56.040 --> 00:29:59.230
And that's how we know, for instance, fat burns at nine

535
00:29:59.230 --> 00:30:02.360
calories per gram, protein burns at four

536
00:30:02.360 --> 00:30:06.410
calories per gram, carbohydrate burns at four calories per gram

537
00:30:06.410 --> 00:30:08.760
, which is why fat is more energy

538
00:30:08.760 --> 00:30:12.200
dense than protein or carbohydrate, which is how we all

539
00:30:12.200 --> 00:30:14.200
determine the fat major fat.

540
00:30:14.200 --> 00:30:17.560
And the bomb calorimeter is also how they determine if a bag of

541
00:30:17.560 --> 00:30:18.840
crisps or chips, whatever you call

542
00:30:18.840 --> 00:30:22.430
here is 200 calories, because if you put them in there, it will

543
00:30:22.430 --> 00:30:24.440
release 200 calories of

544
00:30:24.440 --> 00:30:29.390
energy. Because a calorie is that amount of energy that raises

545
00:30:29.390 --> 00:30:30.920
one gram of water, one degree

546
00:30:30.920 --> 00:30:34.360
centigrade. So it is a measure of physics. So the measure of

547
00:30:34.360 --> 00:30:36.040
heat generation, okay.

548
00:30:36.040 --> 00:30:41.770
Mitochondria are not bomb calorimeters. They are not capturing

549
00:30:41.770 --> 00:30:44.040
heat. They are giving off heat.

550
00:30:44.040 --> 00:30:50.450
They are capturing ATP. No bomb calorimeter captures ATP. Mit

551
00:30:50.450 --> 00:30:53.400
ochondria capture and generate ATP.

552
00:30:53.400 --> 00:30:59.480
Now turns out 35 to 40% of what mitochondria generate turns out

553
00:30:59.480 --> 00:31:00.040
to be heat.

554
00:31:00.040 --> 00:31:05.760
That's why you have a body temperature is from that. And so you

555
00:31:05.760 --> 00:31:08.680
will never have a 100%

556
00:31:08.680 --> 00:31:12.310
energy efficient mitochondria. Because if you did, okay, you

557
00:31:12.310 --> 00:31:15.560
would have a body temperature of,

558
00:31:15.560 --> 00:31:18.780
you know, room temperature, okay, and you'd be dead. That's not

559
00:31:18.780 --> 00:31:21.640
the way it works. Bottom line,

560
00:31:21.640 --> 00:31:28.720
that transfer of food energy to chemical energy loses energy in

561
00:31:28.720 --> 00:31:31.080
the process, okay.

562
00:31:31.080 --> 00:31:35.270
The bomb calorimeter can't tell the difference, but your

563
00:31:35.270 --> 00:31:37.480
mitochondria can. Ultimately,

564
00:31:38.120 --> 00:31:42.340
it's how efficient are your mitochondria at converting food

565
00:31:42.340 --> 00:31:43.560
energy to ATP?

566
00:31:43.560 --> 00:31:49.240
The bomb calorimeter can't tell you anything about that. So

567
00:31:49.240 --> 00:31:52.040
these two phenomena,

568
00:31:52.040 --> 00:31:56.410
you know, the concept of calories as fuel and the concept of

569
00:31:56.410 --> 00:31:59.400
calories as generators of ATP

570
00:31:59.400 --> 00:32:02.590
have really very little to do with each other. And it turns out

571
00:32:02.590 --> 00:32:04.440
that there are individual

572
00:32:04.440 --> 00:32:07.870
things in food, the famous one is fructose, but there are

573
00:32:07.870 --> 00:32:10.280
others, lectins and others that actually

574
00:32:10.280 --> 00:32:15.340
inhibit the mitochondrial generation of ATP. So they actually

575
00:32:15.340 --> 00:32:17.320
inhibit your ability to turn food

576
00:32:17.320 --> 00:32:22.000
energy into chemical energy. If that's the case, even if they

577
00:32:22.000 --> 00:32:23.960
have calories per gram and a bomb

578
00:32:23.960 --> 00:32:27.150
calorimeter, if they're interfering with mitochondrial function

579
00:32:27.150 --> 00:32:30.120
, are they food?

580
00:32:32.520 --> 00:32:35.480
What is the definition of food, substrate that contributes

581
00:32:35.480 --> 00:32:37.640
either to growth or burning of an organism?

582
00:32:37.640 --> 00:32:41.690
Well, I just told you, fructose actually inhibits burning.

583
00:32:41.690 --> 00:32:44.920
Turns out, fructose also inhibits growth,

584
00:32:44.920 --> 00:32:47.670
it inhibits cortical bone growth, trabecular bone growth,

585
00:32:47.670 --> 00:32:50.120
cancels bone growth, bottom line,

586
00:32:50.120 --> 00:32:54.710
people who eat ultra-process food end up shorter. We have the

587
00:32:54.710 --> 00:32:59.560
data for that. So if a substrate that

588
00:32:59.560 --> 00:33:02.880
passes your lips does not contribute to growth and does not

589
00:33:02.880 --> 00:33:05.880
contribute to burning, is it a food?

590
00:33:05.880 --> 00:33:11.480
I guess not. I guess not. What is it then? It's a poison.

591
00:33:11.480 --> 00:33:16.440
And how much of our diet do you think is poison? I found out.

592
00:33:16.440 --> 00:33:22.100
Ultra-process food is loaded with them. Real food is not loaded

593
00:33:22.100 --> 00:33:24.440
with them. You can still find them,

594
00:33:24.440 --> 00:33:28.760
but not loaded with them. Ultra-process food has, in my opinion

595
00:33:28.760 --> 00:33:32.200
, five things wrong with it.

596
00:33:32.200 --> 00:33:37.860
Too much sugar, which poisons your mitochondria. Not in a fiber

597
00:33:37.860 --> 00:33:40.040
, which is necessary to suppress

598
00:33:40.040 --> 00:33:44.260
inflammation. Not enough omega, three fatty acids, which are

599
00:33:44.260 --> 00:33:47.000
necessary to build your brain, conduct

600
00:33:47.000 --> 00:33:51.060
neurotransmission. Too many emulsifiers, which leads to gut

601
00:33:51.060 --> 00:33:53.480
inflammation and therefore systemic

602
00:33:53.480 --> 00:33:56.800
inflammation. And then we can throw on top of that. The food

603
00:33:56.800 --> 00:33:58.600
dies in food additives, which are

604
00:33:58.600 --> 00:34:02.380
mutagenic because they're, you know, petroleum-based. That's

605
00:34:02.380 --> 00:34:03.800
ultra-process food.

606
00:34:03.800 --> 00:34:07.600
Ultra-process food has been associated with every single one of

607
00:34:07.600 --> 00:34:08.600
these diseases,

608
00:34:08.600 --> 00:34:12.700
including every single mental health disease, especially

609
00:34:12.700 --> 00:34:15.320
dementia, as we now have seen.

610
00:34:15.320 --> 00:34:18.760
Ultra-process food is specifically associated with dementia.

611
00:34:18.760 --> 00:34:21.320
And even diet sweeteners are associated

612
00:34:21.320 --> 00:34:25.120
with dementia through this reactive oxygen species pathway. The

613
00:34:25.120 --> 00:34:27.080
sugar industry can't be your

614
00:34:27.080 --> 00:34:32.300
biggest fan. They're not. I'm trying to help them, though. You

615
00:34:32.300 --> 00:34:34.840
know, I am trying to help them.

616
00:34:34.840 --> 00:34:41.510
Last year, not too long after we had our previous session, I

617
00:34:41.510 --> 00:34:44.440
was the keynote speaker

618
00:34:45.080 --> 00:34:48.680
at the fourth international sugar reduction summit in Atlanta,

619
00:34:48.680 --> 00:34:52.120
Georgia, Daniel and the lion's

620
00:34:52.120 --> 00:34:57.640
dead. And, you know, like, why would they invite me? I am, you

621
00:34:57.640 --> 00:34:59.480
know, I'm their conscience.

622
00:34:59.480 --> 00:35:01.950
I said, I told them, I said, I don't want to be your enemy. I

623
00:35:01.950 --> 00:35:03.320
want to be your conscience.

624
00:35:03.320 --> 00:35:07.760
I want you to do the right thing. Okay. Ultimately, look, ultra

625
00:35:07.760 --> 00:35:09.800
-process food's not going away.

626
00:35:09.800 --> 00:35:13.000
As much as I would like it to, it's not going to go away. And I

627
00:35:13.000 --> 00:35:14.360
'm not even sure we wanted to go away

628
00:35:14.360 --> 00:35:17.580
because we got to feed 10 billion people by the year 2050. And

629
00:35:17.580 --> 00:35:18.840
we're not going to have enough land

630
00:35:18.840 --> 00:35:24.750
and ocean to do it. Ultimately, ultra-process food is here to

631
00:35:24.750 --> 00:35:28.280
stay. It is baked into the cake.

632
00:35:28.280 --> 00:35:37.080
But the question is, can we make ultra-process food healthy?

633
00:35:39.000 --> 00:35:44.370
Right now, they're not. Right now, what's going on in the U.S.

634
00:35:44.370 --> 00:35:48.280
food industry is doing the exact opposite.

635
00:35:48.280 --> 00:35:53.620
It's making food disastrously disease-producing. The question

636
00:35:53.620 --> 00:35:56.680
is, could you change that? And the

637
00:35:56.680 --> 00:36:00.270
answer is yes, you can. In fact, we've done it. We have been

638
00:36:00.270 --> 00:36:04.920
doing it. Five years ago, I started

639
00:36:04.920 --> 00:36:09.310
working with an offshore food company, Gratus, by the way, no

640
00:36:09.310 --> 00:36:11.640
money, changed hands. And so,

641
00:36:11.640 --> 00:36:14.210
they came to me and they said, look, we know we're part of the

642
00:36:14.210 --> 00:36:15.720
problem. We want to be part of the

643
00:36:15.720 --> 00:36:20.450
solution. We know that Kuwait has an 18% diabetes rate and an

644
00:36:20.450 --> 00:36:22.920
80% obesity rate. And we don't want

645
00:36:22.920 --> 00:36:28.400
to be the reason. We want to be the help. Can you help us

646
00:36:28.400 --> 00:36:32.760
figure out how to make metabolically

647
00:36:32.760 --> 00:36:39.070
healthy processed food? So, I convened a scientific advisory

648
00:36:39.070 --> 00:36:42.600
team of five members. And we worked for

649
00:36:42.600 --> 00:36:48.260
the next three years, looked at every single process, every

650
00:36:48.260 --> 00:36:52.440
procedure, every vendor, every ingredient,

651
00:36:52.440 --> 00:36:56.180
every product, sent them all for biochemical analysis. To

652
00:36:56.180 --> 00:36:59.000
figure out what's going into the food,

653
00:36:59.000 --> 00:37:02.190
what's coming out of the food is the food metabolically healthy

654
00:37:02.190 --> 00:37:04.040
. What has to be done? How does it

655
00:37:04.040 --> 00:37:08.870
need to be re-engineered to lead to something that is metabol

656
00:37:08.870 --> 00:37:12.280
ically healthy? And we came up with a set

657
00:37:12.280 --> 00:37:16.330
of principles, which we published in Frontiers and Nutrition in

658
00:37:16.330 --> 00:37:18.840
2023. And we call it the metabolic

659
00:37:18.840 --> 00:37:23.810
matrix. And we basically collapsed it down to nine words. Three

660
00:37:23.810 --> 00:37:26.280
clauses, nine words. Protect the

661
00:37:26.280 --> 00:37:32.290
liver, feed the gut, support the brain. That's it. Those three

662
00:37:32.290 --> 00:37:36.600
things. Anything that passes your lips,

663
00:37:36.600 --> 00:37:39.690
that protects the liver, feeds the gut, supports the brain is

664
00:37:39.690 --> 00:37:41.880
healthy, whether it's ultra

665
00:37:41.880 --> 00:37:46.100
processed or not. Anything that passes your lips, that doesn't

666
00:37:46.100 --> 00:37:48.680
none of the three, is poison,

667
00:37:48.680 --> 00:37:52.840
whether it's ultra processed or not. So, it's actually not the

668
00:37:52.840 --> 00:37:54.280
ultra processing.

669
00:37:55.080 --> 00:37:59.500
It's whether or not it contributes to metabolic health. So then

670
00:37:59.500 --> 00:38:03.240
we started re-engineering products

671
00:38:03.240 --> 00:38:09.030
in the KDD line, and they have 180 items in their portfolio. We

672
00:38:09.030 --> 00:38:12.600
have re-engineered 10% of them, 18 products

673
00:38:12.600 --> 00:38:16.650
to become metabolically healthy. And we have tested them on

674
00:38:16.650 --> 00:38:19.880
people in Kuwait to demonstrate

675
00:38:19.880 --> 00:38:23.470
their metabolic benefit. What is there on the shelves now? But

676
00:38:23.470 --> 00:38:24.840
it's in there, is there a trade-off

677
00:38:24.840 --> 00:38:28.640
there? Because those products might sell worse now that they've

678
00:38:28.640 --> 00:38:30.200
removed the stuff that makes

679
00:38:30.200 --> 00:38:36.440
addictive? No. So we didn't tell the public that we were doing

680
00:38:36.440 --> 00:38:39.240
this. We just did it. And they

681
00:38:39.240 --> 00:38:44.470
just reintroduced them to the public and didn't tell them. And

682
00:38:44.470 --> 00:38:46.840
they didn't miss a friggin beat

683
00:38:47.480 --> 00:38:52.840
in terms of sales and in terms of profits. But I mean, tell

684
00:38:52.840 --> 00:38:56.120
them, and it works. Logically though,

685
00:38:56.120 --> 00:39:02.050
the bad stuff often makes the food more addictive. And that's

686
00:39:02.050 --> 00:39:04.040
why this is so cool.

687
00:39:04.040 --> 00:39:09.960
It didn't change consumption and it didn't change profits. And

688
00:39:09.960 --> 00:39:12.280
that's what they care about.

689
00:39:12.280 --> 00:39:15.200
Ultimately, I don't care if consumption changes as long as

690
00:39:15.200 --> 00:39:16.120
profits don't.

691
00:39:17.240 --> 00:39:22.440
This can be done by other food industries. We're trying to get

692
00:39:22.440 --> 00:39:25.960
them on board. And, you know,

693
00:39:25.960 --> 00:39:32.060
I have lots to say about RFK. But he has at least convened a

694
00:39:32.060 --> 00:39:35.400
discussion on what's wrong with

695
00:39:35.400 --> 00:39:40.240
ultra-process food. And we're hoping to be able to enter that

696
00:39:40.240 --> 00:39:41.720
conversation.

697
00:39:41.720 --> 00:39:46.520
RFK is the health leader, I guess, ahead of health and human

698
00:39:46.520 --> 00:39:48.920
services here in the United States.

699
00:39:48.920 --> 00:39:51.530
You have a lot to say about him. I have boatloads to say about

700
00:39:51.530 --> 00:39:53.800
him, most of which you can't print.

701
00:39:53.800 --> 00:40:00.240
What's your general opinion of him in his role in what he's

702
00:40:00.240 --> 00:40:01.800
doing, etc?

703
00:40:01.800 --> 00:40:05.830
I've been asked to serve in this administration four times. And

704
00:40:05.830 --> 00:40:07.400
I've said no each time.

705
00:40:08.760 --> 00:40:12.350
And it's not because I don't want to be, I do. But it's because

706
00:40:12.350 --> 00:40:14.680
my opinion and his opinion

707
00:40:14.680 --> 00:40:17.320
would basically get me thrown out after about five seconds.

708
00:40:17.320 --> 00:40:22.200
What's the difference? I wouldn't last a second. What's the

709
00:40:22.200 --> 00:40:22.920
difference in opinion?

710
00:40:22.920 --> 00:40:30.510
All right, RFK has five buckets in his portfolio. Food on mom

711
00:40:30.510 --> 00:40:31.720
board.

712
00:40:33.560 --> 00:40:37.980
Farm of transparency. I'm on board. Chemicals in the

713
00:40:37.980 --> 00:40:40.920
environment. I'm on board.

714
00:40:40.920 --> 00:40:46.360
Water fluoridation. I'm partially on board.

715
00:40:46.360 --> 00:40:49.640
You could get the fluoride out of the water, but first you got

716
00:40:49.640 --> 00:40:50.760
to get the sugar out of the food.

717
00:40:50.760 --> 00:40:53.950
You can't just take the fluoride out of the water or everybody

718
00:40:53.950 --> 00:40:54.120
will get

719
00:40:54.120 --> 00:40:57.040
Mountain Dew mouth all at the same time. And that would be a

720
00:40:57.040 --> 00:40:58.440
complete and utter disaster.

721
00:40:58.440 --> 00:41:03.640
Has to be done in a coordinated public health, PSA driven

722
00:41:03.640 --> 00:41:07.160
campaign with everyone on board, including

723
00:41:07.160 --> 00:41:10.840
the food industry and the medical profession and government.

724
00:41:10.840 --> 00:41:13.050
And to explain that, there's fluoride in the water in the

725
00:41:13.050 --> 00:41:14.600
United States because there's so much

726
00:41:14.600 --> 00:41:17.520
sugar. There's so much sugar in the food. You wouldn't need

727
00:41:17.520 --> 00:41:18.840
fluoride in the water

728
00:41:18.840 --> 00:41:22.270
if you didn't have sugar in the food. Just explain this. So the

729
00:41:22.270 --> 00:41:23.640
United States put fluoride in the

730
00:41:23.640 --> 00:41:27.910
water to stop dental carries, which protects people's teeth,

731
00:41:27.910 --> 00:41:30.280
which protects people's teeth.

732
00:41:30.280 --> 00:41:33.520
The point is that only half the countries in the world have

733
00:41:33.520 --> 00:41:34.760
fluoride in the water.

734
00:41:34.760 --> 00:41:38.130
The others don't. And the reason is because they don't have

735
00:41:38.130 --> 00:41:40.120
sugar in the food. The only reason

736
00:41:40.120 --> 00:41:43.210
you need to put the fluoride in the water is because the sugar

737
00:41:43.210 --> 00:41:45.160
in the food causes the dental carries.

738
00:41:45.720 --> 00:41:51.380
Now, the fluoride reduces the prevalence of dental carries by

739
00:41:51.380 --> 00:41:53.800
about 30 to 40%.

740
00:41:53.800 --> 00:42:01.040
Dental carries cavities by about 30 to 40%. Now, the problem

741
00:42:01.040 --> 00:42:03.880
with fluoride is at high dose,

742
00:42:03.880 --> 00:42:11.320
it can be a neurotoxin. Now, the goal is for public fluor

743
00:42:11.320 --> 00:42:13.240
idation to stay way below that.

744
00:42:14.360 --> 00:42:20.170
Now, do they? Not really. Sometimes they go above. So normal

745
00:42:20.170 --> 00:42:22.760
fluoride concentrations,

746
00:42:22.760 --> 00:42:26.830
when you're doing it as a public health effort, should be

747
00:42:26.830 --> 00:42:29.560
between 0.3 and 0.9 parts per million.

748
00:42:29.560 --> 00:42:34.200
Sometimes it goes up to 1.5 parts per million. And at 1.5, it

749
00:42:34.200 --> 00:42:35.960
becomes a neurotoxin.

750
00:42:35.960 --> 00:42:41.640
So it's a purely dose issue. But one of the reasons why people

751
00:42:41.640 --> 00:42:42.680
are screaming about getting

752
00:42:42.680 --> 00:42:46.460
fluoride out of the water is because it can be a neurotoxin. It

753
00:42:46.460 --> 00:42:48.440
's not supposed to be in doses that

754
00:42:48.440 --> 00:42:55.100
are appropriate. But people don't look at the data. Point is,

755
00:42:55.100 --> 00:42:57.320
you could get the fluoride out of the

756
00:42:57.320 --> 00:43:00.800
water. But if you got the fluoride out of the water and didn't

757
00:43:00.800 --> 00:43:02.440
take the sugar out of the food,

758
00:43:02.440 --> 00:43:06.680
we'd have more dental carries, we'd have more anesthesia, we'd

759
00:43:06.680 --> 00:43:08.040
have more teeth pulling,

760
00:43:08.040 --> 00:43:12.380
we'd have more sepsis, we'd have more dental abscesses, we'd

761
00:43:12.380 --> 00:43:14.600
have more soldiers dying in the field.

762
00:43:14.600 --> 00:43:19.040
It's a matter of national security. So you can't just do it. It

763
00:43:19.040 --> 00:43:24.040
requires a coordinated effort.

764
00:43:24.040 --> 00:43:26.310
Is there anything else you disagree with him on? And then

765
00:43:26.310 --> 00:43:29.320
finally, bucket number five vaccines.

766
00:43:29.320 --> 00:43:35.030
I am a pediatrician. I am not a vaccine expert to be sure. I am

767
00:43:35.030 --> 00:43:37.240
not an immunologist to be sure.

768
00:43:37.800 --> 00:43:40.370
But I am a pediatrician. And I know a lot about vaccines. And I

769
00:43:40.370 --> 00:43:42.520
know a lot about the infectious diseases

770
00:43:42.520 --> 00:43:47.340
that those vaccines were set up to basically prevent. And I

771
00:43:47.340 --> 00:43:50.600
have taken care of all eight

772
00:43:50.600 --> 00:43:54.710
of the diseases that we have child immunizations for, mumps,

773
00:43:54.710 --> 00:43:56.040
measles, rubella,

774
00:43:56.040 --> 00:44:00.600
diphtheria, pertussis, tetanus, H-flu, polio. I've taken care

775
00:44:00.600 --> 00:44:02.040
of all eight of those.

776
00:44:02.040 --> 00:44:05.880
And I will tell you right now, when I take care of those, it's

777
00:44:05.880 --> 00:44:07.480
because of someone who didn't get

778
00:44:07.480 --> 00:44:11.350
vaccinated. And when I take care of those, okay, the chances

779
00:44:11.350 --> 00:44:13.400
are 90% that that kid's going to die.

780
00:44:13.400 --> 00:44:20.130
RFK is not. RFK says he can tell whether someone has

781
00:44:20.130 --> 00:44:22.840
mitochondrial function, dysfunction,

782
00:44:22.840 --> 00:44:27.960
just by looking at them. I'm a mitochondriologist. I can't.

783
00:44:32.040 --> 00:44:38.400
Ultimately, RFK's view of vaccines is, shall we say, his and

784
00:44:38.400 --> 00:44:39.400
his alone.

785
00:44:39.400 --> 00:44:45.160
And it's not shared by the medical community. And I will not be

786
00:44:45.160 --> 00:44:47.480
part and parcel to 3,000 measles

787
00:44:47.480 --> 00:44:56.540
deaths because of a blanket distained for vaccines and vaccine

788
00:44:56.540 --> 00:44:59.320
technology, which has worked beautifully

789
00:44:59.320 --> 00:45:04.610
to save 154 million people on this earth over the last 50 years

790
00:45:04.610 --> 00:45:04.920
.

791
00:45:04.920 --> 00:45:08.600
Yeah, you know, I don't, I don't talk about this stuff a lot.

792
00:45:08.600 --> 00:45:12.840
But I was,

793
00:45:12.840 --> 00:45:17.610
I'm pretty sure at least one of my siblings was saved by

794
00:45:17.610 --> 00:45:20.120
vaccination when we were in Africa

795
00:45:20.120 --> 00:45:25.780
and we had malaria. I think if I'm accurate here, I had malaria

796
00:45:25.780 --> 00:45:27.640
. My brother's had malaria.

797
00:45:27.640 --> 00:45:30.860
And I think I was the one that didn't get the malaria vaccine

798
00:45:30.860 --> 00:45:32.520
and then I ended up in

799
00:45:32.520 --> 00:45:35.180
hospital as a very young age with with malaria. I was like

800
00:45:35.180 --> 00:45:37.000
hallucinating and stuff like that.

801
00:45:37.000 --> 00:45:42.660
And obviously as someone that was born in Africa, I think you

802
00:45:42.660 --> 00:45:45.080
probably have a clearer understanding

803
00:45:45.080 --> 00:45:50.760
of the role that vaccines can play in in good health. You know,

804
00:45:50.760 --> 00:45:52.360
it's, it's, it's, um, it's quite

805
00:45:52.360 --> 00:45:56.480
concerning because when you speak to any scientist like all of

806
00:45:56.480 --> 00:45:57.880
the majority of the living scientists,

807
00:45:57.880 --> 00:46:03.360
they're very extremely pro, pro vaccine. But we've seen both

808
00:46:03.360 --> 00:46:05.640
sides. We've seen what happens

809
00:46:05.640 --> 00:46:07.930
when there's no vaccine and we've seen what happens when there

810
00:46:07.930 --> 00:46:09.800
is vaccine. And this is not to say

811
00:46:09.800 --> 00:46:13.230
that there can be side effects to vaccines. And the vaccine

812
00:46:13.230 --> 00:46:15.240
manufacturers and scientists talk

813
00:46:15.240 --> 00:46:17.450
about those side effects as well. But the, the thing that I

814
00:46:17.450 --> 00:46:19.240
think people should focus on is the net,

815
00:46:20.440 --> 00:46:24.810
go to that vaccines have done for, for the last centuries in

816
00:46:24.810 --> 00:46:27.560
eradicating illnesses and avoiding

817
00:46:27.560 --> 00:46:31.720
disease. And my concern, just to close off this point is my

818
00:46:31.720 --> 00:46:34.120
concern is if there is to be some kind

819
00:46:34.120 --> 00:46:39.280
of outbreak, anytime soon, we're in such a cloud of

820
00:46:39.280 --> 00:46:42.600
misinformation around vaccines that I,

821
00:46:42.600 --> 00:46:46.190
I worry people might make the wrong decisions. Interestingly,

822
00:46:46.190 --> 00:46:48.040
there was a measles outbreak in Texas

823
00:46:48.040 --> 00:46:51.820
recently in RFK at one point, did eventually prompt the federal

824
00:46:51.820 --> 00:46:55.880
deployment of M, M, M, our MMR vaccines

825
00:46:55.880 --> 00:46:59.220
and expressed support for them. Um, because there was a big

826
00:46:59.220 --> 00:47:01.480
outbreak of measles in, in Texas

827
00:47:01.480 --> 00:47:05.070
very recently. I'm going to tell you something now that I have

828
00:47:05.070 --> 00:47:06.760
not talked about in public.

829
00:47:06.760 --> 00:47:12.420
I had a half an hour with RFK on the phone one on one back in

830
00:47:12.420 --> 00:47:17.240
December of 2024. After the Trump,

831
00:47:17.240 --> 00:47:22.900
uh, election and RFK was starting to convene his, um, team. And

832
00:47:22.900 --> 00:47:25.880
I was asked to join it. And so I got

833
00:47:25.880 --> 00:47:30.070
a half hour with him. And I will relate to you now for your

834
00:47:30.070 --> 00:47:32.520
public so that they understand

835
00:47:32.520 --> 00:47:39.760
what that conversation entailed. Basically two threads, by the

836
00:47:39.760 --> 00:47:41.320
way, we're supposed to talk about

837
00:47:41.320 --> 00:47:44.910
food. We didn't talk about food. We talked about vaccines. And

838
00:47:44.910 --> 00:47:46.920
here were the two threads. First

839
00:47:46.920 --> 00:47:53.070
thread, there are three papers in the medical literature that

840
00:47:53.070 --> 00:47:56.040
say that vaccines do more harm than

841
00:47:56.040 --> 00:48:00.810
good. And he quoted them at me. And I wrote them down. And I

842
00:48:00.810 --> 00:48:03.560
went and looked them up afterwards.

843
00:48:03.560 --> 00:48:07.920
And indeed they say where he says they said that it's unconsc

844
00:48:07.920 --> 00:48:09.240
ionable that

845
00:48:10.520 --> 00:48:13.820
vaccines do more harm than good. And we're giving them to

846
00:48:13.820 --> 00:48:20.200
newborns. No, it is true that those three papers do

847
00:48:20.200 --> 00:48:24.920
say this. There are 50,000 that say opposite. Okay. Second

848
00:48:24.920 --> 00:48:28.680
thing he said, a woman gives birth to a healthy

849
00:48:28.680 --> 00:48:34.000
baby. That healthy baby gets a shot under the skin. And now

850
00:48:34.000 --> 00:48:36.680
that baby is not healthy anymore.

851
00:48:38.600 --> 00:48:45.270
That's a tort, a legal tort. Okay. And in fact, you could argue

852
00:48:45.270 --> 00:48:47.960
that that is a, in fact, a legal tort

853
00:48:47.960 --> 00:48:52.620
because, you know, duty, negligence, you know, all the way down

854
00:48:52.620 --> 00:48:54.840
to damages. Okay.

855
00:48:54.840 --> 00:49:00.840
What's the remedy for tort? I said lawsuit. He says, right. But

856
00:49:00.840 --> 00:49:02.760
that mom can't sue because of

857
00:49:02.760 --> 00:49:08.420
the vaccine and demnification act of 1986. So that mom

858
00:49:08.420 --> 00:49:11.480
basically has a damaged baby and no

859
00:49:11.480 --> 00:49:16.680
recourse. That's unconstitutional. Those were the two threads

860
00:49:16.680 --> 00:49:20.040
of our half hour discussion.

861
00:49:23.960 --> 00:49:30.340
Everything he said is absolutely true and irrelevant. They

862
00:49:30.340 --> 00:49:36.040
demonstrate basically confirmation bias

863
00:49:36.040 --> 00:49:42.740
and he's a lawyer. He believes in precedent. I'm a doctor. I

864
00:49:42.740 --> 00:49:44.040
believe in probability.

865
00:49:44.040 --> 00:49:47.830
There's always a risk benefit ratio unless you're a lawyer in

866
00:49:47.830 --> 00:49:49.560
which case there's only risk.

867
00:49:50.680 --> 00:49:54.450
And that's how he sees the world. She's the world is risk. I

868
00:49:54.450 --> 00:49:58.840
don't. I wouldn't have lasted five seconds.

869
00:49:58.840 --> 00:50:03.550
I think we're both on the same page in terms of making sure

870
00:50:03.550 --> 00:50:06.840
people have the right information

871
00:50:06.840 --> 00:50:09.660
as it relates to probability. We, you know, everything we do in

872
00:50:09.660 --> 00:50:11.080
our life is a factor of probability.

873
00:50:11.080 --> 00:50:14.550
Whether I got a taxi to come here this morning, I understood

874
00:50:14.550 --> 00:50:16.360
the probability of that taxi

875
00:50:16.360 --> 00:50:18.980
crashing into another car, but I decided to get in the car and

876
00:50:18.980 --> 00:50:19.960
come here anyway.

877
00:50:19.960 --> 00:50:26.560
We all deal with these risks every single day. I want to say on

878
00:50:26.560 --> 00:50:27.800
this on this point of

879
00:50:27.800 --> 00:50:32.250
vaccines that there's obviously it's almost but it's become

880
00:50:32.250 --> 00:50:33.640
quite a political issue and there's

881
00:50:33.640 --> 00:50:38.950
two, there's two sides. And one side, which is more of the RFK

882
00:50:38.950 --> 00:50:41.160
side, is incredibly skeptical.

883
00:50:41.160 --> 00:50:46.350
They have their opinion. Then there's the other side which

884
00:50:46.350 --> 00:50:48.360
tends to be dominated more by

885
00:50:48.360 --> 00:50:52.120
the scientists, if I interview scientists a lot. So I know that

886
00:50:52.120 --> 00:50:53.160
pretty much everyone I've interviewed

887
00:50:53.160 --> 00:50:56.110
that's a scientist would agree that, you know, there's there

888
00:50:56.110 --> 00:50:57.160
are side effects but

889
00:50:57.160 --> 00:51:04.950
net net vaccines. It depends on how you look at it. If you look

890
00:51:04.950 --> 00:51:08.200
at it through a public health lens,

891
00:51:08.200 --> 00:51:14.800
the vaccines do more good than harm. And and if you look at it

892
00:51:14.800 --> 00:51:17.320
from a purely individual lens,

893
00:51:19.160 --> 00:51:24.410
then you say, wait a second. I didn't get the disease, but I

894
00:51:24.410 --> 00:51:28.120
got the shot and I have a vaccine

895
00:51:28.120 --> 00:51:32.020
injury. Therefore, I have been subjected to a tort. I would

896
00:51:32.020 --> 00:51:33.480
just like to close this

897
00:51:33.480 --> 00:51:36.670
section by telling people that if there is a health crisis in

898
00:51:36.670 --> 00:51:38.280
the near future, some kind of

899
00:51:38.280 --> 00:51:42.080
viral outbreak, like we saw with the pandemic, to make sure you

900
00:51:42.080 --> 00:51:44.280
get your information from sources

901
00:51:44.280 --> 00:51:47.480
that are highly credible. And those sorts of should not include

902
00:51:47.480 --> 00:51:50.200
, they should not include,

903
00:51:50.200 --> 00:51:53.690
frankly, they should not include podcasts. They should they

904
00:51:53.690 --> 00:51:56.520
should not include social media,

905
00:51:56.520 --> 00:51:59.710
they should include places like I'd recommend checking out a

906
00:51:59.710 --> 00:52:01.480
website called consensus. I have no

907
00:52:01.480 --> 00:52:04.800
affiliation with them, but consensus allows you to type in a

908
00:52:04.800 --> 00:52:06.920
question you have about health

909
00:52:06.920 --> 00:52:11.400
vaccines, whatever it might be. And it shows you what the peer

910
00:52:11.400 --> 00:52:14.440
reviewed studies say and what the

911
00:52:14.440 --> 00:52:17.080
consensus is. So for example, I was I was using the website a

912
00:52:17.080 --> 00:52:18.760
couple of days ago to try and understand

913
00:52:18.760 --> 00:52:22.360
something. My type in, does this particular, is this particular

914
00:52:22.360 --> 00:52:24.120
thing healthy or unhealthy? And it

915
00:52:24.120 --> 00:52:26.340
comes up with this bar, the team will show it on the screen.

916
00:52:26.340 --> 00:52:27.480
And it shows you how much of the

917
00:52:27.480 --> 00:52:31.360
scientific research supports that idea. So it said like 70% of

918
00:52:31.360 --> 00:52:32.760
the scientific research says it

919
00:52:32.760 --> 00:52:37.150
was positive. It said 25% said it was neutral. And 5% said we

920
00:52:37.150 --> 00:52:40.520
kind of don't know or all negative.

921
00:52:40.520 --> 00:52:43.350
And I think that's a really great tool because there's so much

922
00:52:43.350 --> 00:52:44.840
information out there. And there's

923
00:52:44.840 --> 00:52:46.790
so many studies and there's one study that says this and

924
00:52:46.790 --> 00:52:48.680
another that says this. So using tools like

925
00:52:48.680 --> 00:52:51.870
that I think is a much better way to make your health decisions

926
00:52:51.870 --> 00:52:53.320
than podcasts like this or

927
00:52:53.320 --> 00:52:59.160
TikToks or Instagrams or tweets because nothing I want to say

928
00:52:59.160 --> 00:53:00.600
is you might not know this. I'm

929
00:53:00.600 --> 00:53:03.520
just speaking directly to my audience here, but you're

930
00:53:03.520 --> 00:53:06.200
currently in an algorithmic echo chamber. And

931
00:53:06.200 --> 00:53:08.650
if you want to know what I mean by that is the algorithm that

932
00:53:08.650 --> 00:53:10.760
you have on any of your feeds has been

933
00:53:10.760 --> 00:53:13.970
personalized to give you more of the stuff that either scares

934
00:53:13.970 --> 00:53:16.600
you, frightens you, concerns you,

935
00:53:16.600 --> 00:53:19.430
et cetera. And if you want to prove this, go and ask your best

936
00:53:19.430 --> 00:53:21.160
friend or someone else a member of the

937
00:53:21.160 --> 00:53:24.940
public to look at their feed. I had really, I remember probably

938
00:53:24.940 --> 00:53:26.680
two years ago I asked my best friend

939
00:53:26.680 --> 00:53:30.730
if I could just look at his Twitter feed. And it was completely

940
00:53:30.730 --> 00:53:32.600
different from mine. For one,

941
00:53:32.600 --> 00:53:35.070
there was no Manchester United and it was all livable. But then

942
00:53:35.070 --> 00:53:36.440
all of the information was

943
00:53:36.440 --> 00:53:39.630
completely different as well. And so we're living in these echo

944
00:53:39.630 --> 00:53:41.720
chambers where misinformation or

945
00:53:41.720 --> 00:53:43.810
things we believe it's been reinforced positively and

946
00:53:43.810 --> 00:53:45.640
negatively. So you need a strategy for

947
00:53:45.640 --> 00:53:48.210
information, especially as it relates to health. I couldn't

948
00:53:48.210 --> 00:53:49.880
agree more. The fact matter is

949
00:53:50.600 --> 00:53:56.260
these algorithms are designed to keep you engaged. They are not

950
00:53:56.260 --> 00:53:58.120
designed to keep you informed.

951
00:53:58.120 --> 00:54:02.340
It's just that simple. The other problem, of course, is

952
00:54:02.340 --> 00:54:05.000
confirmation bias. If you have confirmation

953
00:54:05.000 --> 00:54:08.770
bias, you will only seek out the information that reconfirms

954
00:54:08.770 --> 00:54:11.560
your bias. And that's what we

955
00:54:11.560 --> 00:54:14.540
didn't used to have, but that's what we have now. That's what's

956
00:54:14.540 --> 00:54:15.480
about to play out in the comment

957
00:54:15.480 --> 00:54:19.220
section whenever we talk about subjects like vaccines is, there

958
00:54:19.220 --> 00:54:21.480
will be a group of people who have

959
00:54:21.480 --> 00:54:24.390
their own opinions on it and you're entitled to your opinion.

960
00:54:24.390 --> 00:54:26.520
And they will go at war to confirm

961
00:54:26.520 --> 00:54:28.140
and prove that opinion. And there will be another group of

962
00:54:28.140 --> 00:54:29.240
people who have a different opinion.

963
00:54:29.240 --> 00:54:32.610
And they'll go at war to confirm that opinion. What I love and

964
00:54:32.610 --> 00:54:35.480
hopefully what I think my audience

965
00:54:35.480 --> 00:54:43.630
understand me for is I try and remain open minded. And that's

966
00:54:43.630 --> 00:54:45.720
like a really fucking hard thing to do.

967
00:54:45.720 --> 00:54:49.130
I saw a journalist the day they said, they were trying to place

968
00:54:49.130 --> 00:54:51.080
me politically and they said,

969
00:54:51.080 --> 00:54:54.440
we think Stephen is apolitical. And I think that's probably an

970
00:54:54.440 --> 00:54:55.480
app description of my

971
00:54:55.480 --> 00:54:58.310
Indians because I would consider that a high compliment. It's

972
00:54:58.310 --> 00:54:59.480
an amazing compliment.

973
00:54:59.480 --> 00:55:08.080
I have views but I don't sign up to any particular cult. And

974
00:55:08.080 --> 00:55:10.520
you know you're in a cult when you're

975
00:55:10.520 --> 00:55:15.470
views 99% represent the person who's also in the cult because

976
00:55:15.470 --> 00:55:17.560
logically that should never be the

977
00:55:17.560 --> 00:55:21.350
case. That should never be the case. I agree. You know, cults

978
00:55:21.350 --> 00:55:24.040
are a part and parcel of society

979
00:55:24.040 --> 00:55:27.640
unfortunately. I've watched so many entrepreneurs treat sales

980
00:55:27.640 --> 00:55:29.400
like a performance problem when it's

981
00:55:29.400 --> 00:55:32.180
often down to visibility because when you can't see what's

982
00:55:32.180 --> 00:55:33.560
happening in your pipeline,

983
00:55:33.560 --> 00:55:36.800
what stage each conversation is that, what's stalled, what's

984
00:55:36.800 --> 00:55:38.920
moving, you can't improve anything

985
00:55:38.920 --> 00:55:42.550
and you can't close the deal. Our sponsor pipe drive is the

986
00:55:42.550 --> 00:55:44.440
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987
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988
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989
00:55:49.960 --> 00:55:53.670
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990
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991
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992
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994
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995
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996
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997
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998
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1000
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1001
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1002
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1003
00:56:31.320 --> 00:56:36.480
and they have me and you in their ears and they know that sugar

1004
00:56:36.480 --> 00:56:38.200
is bad. They know ultra

1005
00:56:38.200 --> 00:56:43.700
process food is bad. They still are struggling with a little

1006
00:56:43.700 --> 00:56:46.680
bit of fat, other sort of diseases,

1007
00:56:46.680 --> 00:56:49.250
they're probably on the trajectory to some form of chronic

1008
00:56:49.250 --> 00:56:50.760
disease, maybe Alzheimer's, maybe

1009
00:56:50.760 --> 00:56:54.260
dementia, maybe a form of cancer. What do we have if we're

1010
00:56:54.260 --> 00:56:57.800
talking, let's name her or him? Let's call her

1011
00:56:57.800 --> 00:57:01.850
Jenny. Jenny's listening right now. Jenny and Dave, they're

1012
00:57:01.850 --> 00:57:03.480
both sat there, they're the average

1013
00:57:03.480 --> 00:57:07.800
American. What do we say to Jenny and Dave to get them to

1014
00:57:07.800 --> 00:57:11.880
change their lives? The first thing

1015
00:57:12.840 --> 00:57:19.060
that you have to say to them is, who are you? Do you know? Do

1016
00:57:19.060 --> 00:57:23.240
you know who you are? Because if they don't

1017
00:57:23.240 --> 00:57:27.570
know who they are, then nothing else is going to matter. They

1018
00:57:27.570 --> 00:57:29.720
have to be comfortable in their own

1019
00:57:29.720 --> 00:57:34.630
skin and they're not. The reason that they have glommed on to

1020
00:57:34.630 --> 00:57:37.480
ultra-process food is it's providing them

1021
00:57:38.840 --> 00:57:45.160
with a dopamine hit. It's probably the only thing that even

1022
00:57:45.160 --> 00:57:47.480
remotely gives them pleasure.

1023
00:57:47.480 --> 00:57:52.760
And if that's all the pleasure they get in their lives, you're

1024
00:57:52.760 --> 00:57:55.880
never going to fix it because that's

1025
00:57:55.880 --> 00:58:03.440
all they've got. So the question is, sorting your priorities at

1026
00:58:03.440 --> 00:58:07.080
the individual level, what's

1027
00:58:07.080 --> 00:58:11.930
important to you? What's a primary importance? Love,

1028
00:58:11.930 --> 00:58:16.200
relationships. What's a secondary importance?

1029
00:58:16.200 --> 00:58:24.510
Pleasure, food, drugs. If you don't have any of the love,

1030
00:58:24.510 --> 00:58:26.440
relationships, stability

1031
00:58:26.440 --> 00:58:32.570
in your life, there's no amount of food or drugs that's going

1032
00:58:32.570 --> 00:58:34.600
to be able to make up for that.

1033
00:58:36.040 --> 00:58:40.090
So who are you? What is it that really matters to you? And

1034
00:58:40.090 --> 00:58:42.360
until you answer that question,

1035
00:58:42.360 --> 00:58:45.800
honestly and affirmatively, you're never going to get past us.

1036
00:58:45.800 --> 00:58:49.320
So let me roleplay as Jenny and Dave.

1037
00:58:49.320 --> 00:58:54.440
You've asked me, who am I? I am 30 years old and I work this

1038
00:58:54.440 --> 00:58:57.240
job. I don't, it drops okay. I don't

1039
00:58:57.240 --> 00:59:00.600
love it. It's not lighting me up. I'm single. I'm living in

1040
00:59:00.600 --> 00:59:04.360
this, this city. And yeah, I'm just, you know,

1041
00:59:05.160 --> 00:59:09.210
handling along, kind of like on the, on the treadmill of life.

1042
00:59:09.210 --> 00:59:12.040
And how much stress are you under?

1043
00:59:12.040 --> 00:59:14.510
A lot of stress. A whole lot. Every time I open my phone, it's

1044
00:59:14.510 --> 00:59:15.960
stressful, my emails, my work,

1045
00:59:15.960 --> 00:59:18.580
because this thing going on with this person, I think my mom's

1046
00:59:18.580 --> 00:59:19.880
got a problem with this thing

1047
00:59:19.880 --> 00:59:24.040
and how health is deteriorating. So imagine what that's doing

1048
00:59:24.040 --> 00:59:26.360
to the ATP in your brain.

1049
00:59:26.360 --> 00:59:31.130
What's it doing? It's depleting it like crazy. Number one, you

1050
00:59:31.130 --> 00:59:32.520
have mitochondrial dysfunction from

1051
00:59:32.520 --> 00:59:36.110
all the shit you ate. And from the, you know, unfortunately

1052
00:59:36.110 --> 00:59:37.720
from the air pollution you've been

1053
00:59:37.720 --> 00:59:40.680
breathing. And from the microplastics, you know, that have

1054
00:59:40.680 --> 00:59:42.280
basically taken over your brain,

1055
00:59:42.280 --> 00:59:45.200
one two hundredth of your brain right now, Stephen is micropl

1056
00:59:45.200 --> 00:59:47.160
astics, whether you like it or not.

1057
00:59:47.160 --> 00:59:50.460
So Jenny and Dave probably have more. Okay. And you eat well,

1058
00:59:50.460 --> 00:59:54.520
they don't. All right. So here we are.

1059
00:59:54.520 --> 00:59:58.340
This is, this is the, the substrate. This is the base. The

1060
00:59:58.340 --> 01:00:01.240
question is, how are we going to improve

1061
01:00:01.880 --> 01:00:05.470
their ATP generation? How are we going to improve their

1062
01:00:05.470 --> 01:00:07.880
mitochondrial function? How are we going to get

1063
01:00:07.880 --> 01:00:12.300
those, their neurons to start responding properly? That's the

1064
01:00:12.300 --> 01:00:15.560
question. And do you aim stress as part

1065
01:00:15.560 --> 01:00:20.680
of the solution? Yes, of course. You have to. How can you not?

1066
01:00:20.680 --> 01:00:24.200
Let me give you another quick clinical

1067
01:00:24.200 --> 01:00:30.420
event yet? Recently, I had the opportunity to have an extended

1068
01:00:30.420 --> 01:00:34.040
conversation with a hero of mine,

1069
01:00:34.040 --> 01:00:38.090
Dr. Vivek Murthy, who was the former surgeon general of the

1070
01:00:38.090 --> 01:00:40.600
United States. And we were in London

1071
01:00:40.600 --> 01:00:44.630
together. And I finally sat him down and I said, you know, Vive

1072
01:00:44.630 --> 01:00:46.440
k, I love your, you know,

1073
01:00:47.640 --> 01:00:52.170
espousing of love that we ultimately need to love each other to

1074
01:00:52.170 --> 01:00:53.320
get over these

1075
01:00:53.320 --> 01:01:00.660
systemic societal travails that we love is what's missing. Here

1076
01:01:00.660 --> 01:01:03.400
's the problem. You can't love if your

1077
01:01:03.400 --> 01:01:09.130
brain is inflamed. You can't love if you can't love if your

1078
01:01:09.130 --> 01:01:13.720
brain is inflamed. Of course,

1079
01:01:13.720 --> 01:01:18.070
the reason for the inflamed brain is the ultra process food and

1080
01:01:18.070 --> 01:01:19.720
all the things we talked about,

1081
01:01:19.720 --> 01:01:22.500
the reactive oxygen species, the cortisol, etcetera that we

1082
01:01:22.500 --> 01:01:23.640
talked about before.

1083
01:01:23.640 --> 01:01:27.080
So you saying people that are metabolically unhealthy that are

1084
01:01:27.080 --> 01:01:28.360
having inflamed brains that are

1085
01:01:28.360 --> 01:01:34.020
under stress have a reduced ability to love. Yes, it's exactly

1086
01:01:34.020 --> 01:01:37.080
what I'm saying. They can't love

1087
01:01:37.080 --> 01:01:40.390
themselves and they can't love anyone around them. Explain the

1088
01:01:40.390 --> 01:01:44.120
signs that serotonin. What is

1089
01:01:44.120 --> 01:01:48.980
serotonin? Serotonin is a neurotransmitter that is necessary

1090
01:01:48.980 --> 01:01:51.800
for eudimonia for being able to be

1091
01:01:51.800 --> 01:01:55.450
content. Oxytocin is the love neurotransmitter, the

1092
01:01:55.450 --> 01:01:58.440
reproduction neurotransmitter, the safety

1093
01:01:58.440 --> 01:02:04.990
neurotransmitter. The cortisol causes the methylation of the

1094
01:02:04.990 --> 01:02:08.520
oxytocin receptor. Now the oxytocin

1095
01:02:08.520 --> 01:02:13.810
can't work so you can't feel safe and the serotonin is

1096
01:02:13.810 --> 01:02:16.440
necessary to basically suppress that

1097
01:02:16.440 --> 01:02:22.610
inflammation in the amygdala. That's actually causing the bucks

1098
01:02:22.610 --> 01:02:26.840
hot, the inability to surgically

1099
01:02:26.840 --> 01:02:30.340
strike like we talked about before being that lousy point guard

1100
01:02:30.340 --> 01:02:34.440
. So I said to him you can't love

1101
01:02:34.440 --> 01:02:38.950
if your brain is inflamed and he thanked me and he, you know, I

1102
01:02:38.950 --> 01:02:40.120
thought that was the end of that

1103
01:02:40.120 --> 01:02:44.440
and I'm not going to bother him anymore. Two weeks ago, I got

1104
01:02:44.440 --> 01:02:46.600
an email from Vivek saying I thought

1105
01:02:46.600 --> 01:02:49.840
about what you said in half way through your book and let's

1106
01:02:49.840 --> 01:02:52.840
talk. You can't love if your brain is

1107
01:02:52.840 --> 01:02:55.660
inflamed. I was just looking at a study that says high cortisol

1108
01:02:55.660 --> 01:02:57.400
levels in a mom during pregnancy can

1109
01:02:57.400 --> 01:03:00.880
affect the babies, oxytocin receptors, meaning they'll feel

1110
01:03:00.880 --> 01:03:02.440
less safe. Exactly right.

1111
01:03:02.440 --> 01:03:07.240
And epigenetic happens even before birth.

1112
01:03:07.240 --> 01:03:11.290
I'm trying to play out, so I'm trying to form a couple of

1113
01:03:11.290 --> 01:03:13.640
hypotheses here around what this might

1114
01:03:13.640 --> 01:03:16.830
mean in practice. So I mean in the case of the mother, if the

1115
01:03:16.830 --> 01:03:20.280
mother was under a lot of stress

1116
01:03:21.240 --> 01:03:24.850
that resulted in cortisol, then the babies oxytocin receptors

1117
01:03:24.850 --> 01:03:26.920
which are the bonding chemical of

1118
01:03:26.920 --> 01:03:30.280
within humans, the bonding hormone is going to be depleted. So

1119
01:03:30.280 --> 01:03:31.720
if I had a really stressful

1120
01:03:31.720 --> 01:03:39.020
mother during my conception or whatever that don't pregnancy,

1121
01:03:39.020 --> 01:03:41.640
there's a probability,

1122
01:03:41.640 --> 01:03:44.830
there's a causal probability that I might be less good at

1123
01:03:44.830 --> 01:03:46.040
bonding with people.

1124
01:03:46.600 --> 01:03:50.650
There we are. That's exactly what we're saying. But I guess

1125
01:03:50.650 --> 01:03:52.520
also that can take place after pregnancy.

1126
01:03:52.520 --> 01:03:57.800
Yeah, it's a continual process. The question is can it be

1127
01:03:57.800 --> 01:03:59.480
undone and the answer is yes,

1128
01:03:59.480 --> 01:04:01.480
but with a lot of work.

1129
01:04:01.480 --> 01:04:08.330
And you have to have the baseline substrate to be able to do it

1130
01:04:08.330 --> 01:04:08.760
.

1131
01:04:08.760 --> 01:04:13.640
There's a bit of what's the term when something becomes a

1132
01:04:13.640 --> 01:04:15.080
little bit self-fulfilling where

1133
01:04:15.080 --> 01:04:19.320
kind of topology? What I'm saying is if someone's lonely,

1134
01:04:19.320 --> 01:04:22.600
extremely lonely, and they are in a single

1135
01:04:22.600 --> 01:04:27.960
apartment alone, which is increasingly a lot of people, then I

1136
01:04:27.960 --> 01:04:29.560
've raised them in basements.

1137
01:04:29.560 --> 01:04:33.000
Yeah, but even in major cities like London and New York etc. So

1138
01:04:33.000 --> 01:04:33.800
many people live in a little

1139
01:04:33.800 --> 01:04:37.130
shoebox alone. And I saw the studies that show the average

1140
01:04:37.130 --> 01:04:38.680
person used to have XM at

1141
01:04:38.680 --> 01:04:41.520
friends to turn to an atomic crisis. Now they have on average

1142
01:04:41.520 --> 01:04:43.640
it's like one or zero. So loneliness

1143
01:04:43.640 --> 01:04:46.610
is up. And then I also saw some research that said when people

1144
01:04:46.610 --> 01:04:48.360
are lonely, their body goes into

1145
01:04:48.360 --> 01:04:53.730
a state where they sleep worse, they're more stressed, they're

1146
01:04:53.730 --> 01:04:56.120
more bitter to people.

1147
01:04:56.120 --> 01:04:59.480
And I can't remember the term for that, but it's like this

1148
01:04:59.480 --> 01:05:01.720
heightened sensitivity and the thesis

1149
01:05:01.720 --> 01:05:05.180
is that once upon a time in an evolutionary context, if you

1150
01:05:05.180 --> 01:05:07.560
lost your tribe, you would have to be

1151
01:05:07.560 --> 01:05:10.750
more on edge to survive. That's your amygdala. And if that's

1152
01:05:10.750 --> 01:05:12.680
the case then, it means that it would

1153
01:05:12.680 --> 01:05:15.950
stress that if you're lonely, you'll highest stress. Yes, but

1154
01:05:15.950 --> 01:05:17.720
if you're highest stress, you're more likely

1155
01:05:17.720 --> 01:05:21.150
to be lonely. That's right. Which is the vicious cycle. A

1156
01:05:21.150 --> 01:05:22.280
vicious cycle. That's the

1157
01:05:22.280 --> 01:05:24.750
time. That's the vicious cycle. Absolutely. You couldn't agree

1158
01:05:24.750 --> 01:05:27.000
more. That's what we're trying to

1159
01:05:27.000 --> 01:05:31.520
undo. So here's a question for you. Quiz. All right. And you

1160
01:05:31.520 --> 01:05:33.480
know the answer. Okay. Because I've

1161
01:05:33.480 --> 01:05:36.280
mentioned it already on this podcast. All right. You ready?

1162
01:05:36.280 --> 01:05:38.840
Yeah. What is the difference

1163
01:05:39.480 --> 01:05:47.880
between loneliness and solitude? Loneliness is a lack of human

1164
01:05:47.880 --> 01:05:51.080
connection and solitude is being alone.

1165
01:05:51.080 --> 01:05:57.240
Well, both have a lack of human connection. I don't know. Tell

1166
01:05:57.240 --> 01:05:58.040
me the answer. What's the

1167
01:05:58.040 --> 01:06:01.800
serotonin? Okay. If you're serotonin depleted, you're lonely.

1168
01:06:01.800 --> 01:06:04.120
If you're serotonin replete, it's

1169
01:06:04.120 --> 01:06:08.610
solitude. You're comfortable in your loneliness. You're happy

1170
01:06:08.610 --> 01:06:11.720
that you're lonely. Because you're not

1171
01:06:11.720 --> 01:06:14.820
really lonely. You're alone. And how does that happen that I

1172
01:06:14.820 --> 01:06:17.560
become lonely and in terms of the serotonin

1173
01:06:17.560 --> 01:06:22.900
mechanism? Well, you choose to be alone when you're in solitude

1174
01:06:22.900 --> 01:06:25.320
. But the point is that's what you

1175
01:06:25.320 --> 01:06:30.980
want. That's what you chose. You could be with other people.

1176
01:06:30.980 --> 01:06:32.840
You chose them to be in solitude.

1177
01:06:33.480 --> 01:06:38.150
When you're lonely. Okay. The reason even when people are

1178
01:06:38.150 --> 01:06:40.600
coming at you, even when you're at a party

1179
01:06:40.600 --> 01:06:45.280
and you are clearly not lonely, you feel like you are. You feel

1180
01:06:45.280 --> 01:06:48.200
like you're there all by yourself,

1181
01:06:48.200 --> 01:06:51.800
even though all these people are around you. What is serotonin?

1182
01:06:51.800 --> 01:06:52.840
And that's because your

1183
01:06:52.840 --> 01:06:56.890
serotonin depleted. Serotonin is a neurotransmitter. It's made

1184
01:06:56.890 --> 01:06:58.280
from a amino acid called

1185
01:06:58.280 --> 01:07:04.070
tryptophane. Tryptophane is the rarest amino acid in all of the

1186
01:07:04.070 --> 01:07:05.400
proteins that we ingest. It's

1187
01:07:05.400 --> 01:07:09.050
the rarest amino acid on the planet. It's found in eggs,

1188
01:07:09.050 --> 01:07:11.960
chicken, fish, not exactly ultra-processed food.

1189
01:07:11.960 --> 01:07:16.010
So people who eat ultra-processed food at high rate are going

1190
01:07:16.010 --> 01:07:16.360
to be

1191
01:07:16.360 --> 01:07:20.410
tryptophane deficient and therefore serotonin deficient are

1192
01:07:20.410 --> 01:07:22.520
going to be somewhat irritable and also

1193
01:07:22.520 --> 01:07:26.400
somewhat lonely. And what it does is it inhibits the next

1194
01:07:26.400 --> 01:07:30.840
neuron. It causes the next neuron

1195
01:07:30.840 --> 01:07:35.400
not to fire. Instead of dopamine, which causes the next neuron

1196
01:07:35.400 --> 01:07:37.080
to fire, they are very different.

1197
01:07:37.080 --> 01:07:42.280
And serotonin, when it's at normal dose, gives you a feeling of

1198
01:07:42.280 --> 01:07:45.400
contentment. Not necessarily

1199
01:07:45.400 --> 01:07:50.920
happiness, but this feels good. I don't want or need anymore.

1200
01:07:50.920 --> 01:07:53.000
So it's almost the opposite of

1201
01:07:53.000 --> 01:07:56.590
dopamine. It's the exact opposite of dopamine. Dopamine is this

1202
01:07:56.590 --> 01:08:00.040
feels good. I want more. And serotonin

1203
01:08:00.040 --> 01:08:02.950
is this feels good. I don't want or need anymore. And serotonin

1204
01:08:02.950 --> 01:08:05.400
is predominantly made in the gut, 90%.

1205
01:08:05.400 --> 01:08:08.590
So 90% is made in the gut. The question is does the gut

1206
01:08:08.590 --> 01:08:11.000
serotonin get to the brain and the answers

1207
01:08:11.000 --> 01:08:15.050
through the afferent vagus nerve so that afferent vagus has to

1208
01:08:15.050 --> 01:08:18.280
be functional and has to basically conduct

1209
01:08:18.280 --> 01:08:21.890
information from the gut up to the brain in order to be able to

1210
01:08:21.890 --> 01:08:24.680
transduce that. That is what we call

1211
01:08:24.680 --> 01:08:29.930
intuition. That is called gut feeling. So I need my vagus nerve

1212
01:08:29.930 --> 01:08:32.360
to be healthy. Yes, you do.

1213
01:08:32.360 --> 01:08:35.160
And there are a lot of things that are causing that vagus nerve

1214
01:08:35.160 --> 01:08:36.840
not to be healthy, including

1215
01:08:36.840 --> 01:08:39.810
all of the gut inflammation that we talked about from the ultra

1216
01:08:39.810 --> 01:08:41.400
process food. So how do I make my

1217
01:08:41.400 --> 01:08:45.800
vagus not healthy? Eat real food. What about this vagus nerve

1218
01:08:45.800 --> 01:08:46.680
stimulators that everyone's

1219
01:08:46.680 --> 01:08:51.740
banging on about? So they're interesting. And they do have

1220
01:08:51.740 --> 01:08:54.200
benefits for seizure control.

1221
01:08:54.200 --> 01:09:01.560
Okay. For seizures, the vagus nerve for some reason transduces

1222
01:09:01.560 --> 01:09:04.760
information up and down that help

1223
01:09:04.760 --> 01:09:09.680
mitigate seizures. No one's been able to demonstrate to my

1224
01:09:09.680 --> 01:09:12.920
knowledge that you can use a vagal nerve

1225
01:09:12.920 --> 01:09:18.210
stimulator to actually change emotion. I was looking at the

1226
01:09:18.210 --> 01:09:20.120
research and it says exactly what

1227
01:09:20.120 --> 01:09:23.710
you described that a metronolysis in long-term follow-up show a

1228
01:09:23.710 --> 01:09:27.240
30 to 50% reduction in seizures

1229
01:09:27.240 --> 01:09:30.430
patients who use vagal nerve simulation, but outside of that in

1230
01:09:30.430 --> 01:09:32.280
terms of depression, the evidence

1231
01:09:32.280 --> 01:09:40.800
is modest media, around 15 to 25% show, which is above placebo.

1232
01:09:40.800 --> 01:09:43.000
So it's small. And then with

1233
01:09:43.000 --> 01:09:46.200
anxiety, it's the same. There's not there's any low quality and

1234
01:09:46.200 --> 01:09:48.280
small scale work that they do say

1235
01:09:48.280 --> 01:09:51.470
though that implanted vagus nerve stimulators show the

1236
01:09:51.470 --> 01:09:53.880
strongest evidence for epilepsy and depression,

1237
01:09:53.880 --> 01:09:57.480
but the bottom line is it works well for seizures, as you said,

1238
01:09:57.480 --> 01:09:59.400
and they're still a lot

1239
01:09:59.400 --> 01:10:03.880
unproven as it relates to stress and focus. I wish they worked.

1240
01:10:03.880 --> 01:10:05.800
I mean, it would be an easy

1241
01:10:05.800 --> 01:10:08.990
thing. You know, you're one thing you learn from doing what I

1242
01:10:08.990 --> 01:10:11.960
do with this podcast is you learn

1243
01:10:11.960 --> 01:10:15.180
that in life, there are really not many shortcuts and

1244
01:10:15.180 --> 01:10:18.040
everything that appears to be a shortcut,

1245
01:10:18.040 --> 01:10:21.240
some device, some contraption that's going to fix things.

1246
01:10:21.240 --> 01:10:24.120
Actually, either doesn't work is a scam

1247
01:10:24.120 --> 01:10:29.780
or has some hidden trade-off. And so it goes back to this

1248
01:10:29.780 --> 01:10:31.480
really important principle that I think

1249
01:10:31.480 --> 01:10:34.800
everybody listening to your body, which is there's no free

1250
01:10:34.800 --> 01:10:37.000
lunch in life. If it appears to be the

1251
01:10:37.000 --> 01:10:40.850
fast way, it's probably a fast way to something else. And the

1252
01:10:40.850 --> 01:10:42.680
slow way is the fast way. The hard

1253
01:10:42.680 --> 01:10:45.130
way is the fast way. This is kind of what I've learned. I can

1254
01:10:45.130 --> 01:10:47.240
try all these things to try and trick,

1255
01:10:47.240 --> 01:10:51.380
to try and be able to eat sugar, but be healthy. And there's

1256
01:10:51.380 --> 01:10:53.560
always some vacuum trade-off.

1257
01:10:53.560 --> 01:10:56.650
Like even a zempeck, exactly. Everyone's talking about a zempe

1258
01:10:56.650 --> 01:10:59.000
ck. It's a band-aid, not a fix.

1259
01:10:59.000 --> 01:11:02.430
What do you think of a zempeck? How much time you got? It

1260
01:11:02.430 --> 01:11:03.880
depends what you think.

1261
01:11:03.880 --> 01:11:08.860
People ask me this all the time. I wear three hats. So I'll put

1262
01:11:08.860 --> 01:11:11.640
my first hat on, my clinician hat.

1263
01:11:11.640 --> 01:11:16.700
I'm glad they're here. These GOP one analogues, they do work. I

1264
01:11:16.700 --> 01:11:18.200
'm not saying they don't. They do.

1265
01:11:19.080 --> 01:11:24.030
And God knows if you have a BMI of 40 to 45 and you have tried

1266
01:11:24.030 --> 01:11:26.760
everything else and nothing else works

1267
01:11:26.760 --> 01:11:29.410
and it's a matter of life and death, then I am glad they're

1268
01:11:29.410 --> 01:11:32.440
here. All right, now let me put my second

1269
01:11:32.440 --> 01:11:37.500
hat on. My scientists hat. Okay, why do they work? They work in

1270
01:11:37.500 --> 01:11:40.120
two places. They work actually

1271
01:11:40.120 --> 01:11:43.720
at that nucleus accumbens, which I mentioned before, the reward

1272
01:11:43.720 --> 01:11:45.320
center. It actually seems to

1273
01:11:45.320 --> 01:11:48.510
reduce reward. It's one of the reasons why GOP One analogues

1274
01:11:48.510 --> 01:11:50.440
are not just being used for obesity,

1275
01:11:50.440 --> 01:11:56.200
but for alcoholism, for drug addiction, for many things,

1276
01:11:56.200 --> 01:11:57.720
because they're basically putting that

1277
01:11:57.720 --> 01:12:03.040
reward system to rest, which is a good thing. Now, we had a

1278
01:12:03.040 --> 01:12:06.520
drug that did that back in 2006,

1279
01:12:06.520 --> 01:12:09.840
put that reward system to rest. It was called Ramana-Bant, a

1280
01:12:09.840 --> 01:12:11.800
trade name, a complea.

1281
01:12:12.600 --> 01:12:19.800
And what it was was an anti-Indo-Canabinoid. It was an Indo-Can

1282
01:12:19.800 --> 01:12:21.800
abinoid receptor antagonist. It was

1283
01:12:21.800 --> 01:12:26.080
the anti-Marawana drug. It was the anti-Munchies drug. And so

1284
01:12:26.080 --> 01:12:29.320
it caused weight loss. And it got released

1285
01:12:29.320 --> 01:12:34.740
in the European Union, the EFSA approved it in 2006. And within

1286
01:12:34.740 --> 01:12:37.160
two months of its hitting the market,

1287
01:12:37.160 --> 01:12:43.350
there were 21 suicides. And the reason is because if you

1288
01:12:43.350 --> 01:12:44.280
suppress reward,

1289
01:12:44.280 --> 01:12:50.840
ain't no reason to get out of bed in the morning. Now, the good

1290
01:12:50.840 --> 01:12:53.240
news with these GOP One analogues is

1291
01:12:53.240 --> 01:12:56.440
we've been looking for the suicide signal and haven't seen it.

1292
01:12:56.440 --> 01:12:58.760
But we also are looking for the

1293
01:12:58.760 --> 01:13:03.270
depression signal, and we see that a lot. So it does seem to be

1294
01:13:03.270 --> 01:13:05.000
having the same effect,

1295
01:13:05.000 --> 01:13:08.780
maybe not as severe as Ramana-Bant, but nonetheless, that's a

1296
01:13:08.780 --> 01:13:10.120
downside for sure.

1297
01:13:10.120 --> 01:13:15.110
Okay. Now, the second place it works, GI tract. It delays gast

1298
01:13:15.110 --> 01:13:18.040
ric emptying. It slows

1299
01:13:18.040 --> 01:13:21.710
food going through the elementary canal, especially the stomach

1300
01:13:21.710 --> 01:13:24.840
. Okay. That's why it works,

1301
01:13:24.840 --> 01:13:28.040
because you can't eat more if your stomach's still full,

1302
01:13:28.040 --> 01:13:29.560
because it didn't move it along.

1303
01:13:30.360 --> 01:13:34.590
Okay, that's good sort of, except it gives you all the side

1304
01:13:34.590 --> 01:13:37.000
effects, the nausea, the vomiting,

1305
01:13:37.000 --> 01:13:42.660
the pancreatitis, the gastroparuses. Stomach turns to stone 3.4

1306
01:13:42.660 --> 01:13:44.520
percent of all people who take

1307
01:13:44.520 --> 01:13:49.400
GOP One analogues get gastroparuses. And guess what? When you

1308
01:13:49.400 --> 01:13:51.720
stop the med, the gastroparuses

1309
01:13:51.720 --> 01:13:55.310
doesn't go away. And there is a lawsuit against Novonortis

1310
01:13:55.310 --> 01:13:57.160
right now over gastroparuses,

1311
01:13:57.960 --> 01:14:02.600
from GOP One analogues. Not so good. In addition,

1312
01:14:02.600 --> 01:14:08.000
you lose weight. Okay. Well, kind of weight. Turns out half

1313
01:14:08.000 --> 01:14:11.240
muscle, half fat. Now, losing fat's good.

1314
01:14:11.240 --> 01:14:16.300
Losing muscle is not. Losing muscle is actually a risk factor

1315
01:14:16.300 --> 01:14:17.320
for early demise.

1316
01:14:17.320 --> 01:14:21.560
Sarcopenia is a risk factor for early demise. Now, what else

1317
01:14:21.560 --> 01:14:23.560
causes loss of equal amounts of

1318
01:14:23.560 --> 01:14:28.120
muscle and fat? Starvation. And that's how the damn medicine's

1319
01:14:28.120 --> 01:14:30.120
work. They're causing you to starve.

1320
01:14:30.120 --> 01:14:35.550
Well, that's not the best way to do this, people. Also, only

1321
01:14:35.550 --> 01:14:38.440
one third of people who take

1322
01:14:38.440 --> 01:14:41.680
GOP One analogues actually respond. Two thirds don't. They don

1323
01:14:41.680 --> 01:14:43.000
't tell you about those. They're

1324
01:14:43.000 --> 01:14:46.190
only telling you about the responders. And as soon as you stop

1325
01:14:46.190 --> 01:14:47.880
taking it, all the way comes rushing

1326
01:14:47.880 --> 01:14:51.070
back plus some because you've only bandated the problem you

1327
01:14:51.070 --> 01:14:54.200
haven't fixed the problem. Also,

1328
01:14:54.200 --> 01:14:57.690
not such a great thing. And then finally, let me switch to my

1329
01:14:57.690 --> 01:14:58.360
third hat,

1330
01:14:58.360 --> 01:15:03.640
my public health advocate hat. Now, I did say these drugs work.

1331
01:15:03.640 --> 01:15:07.080
16% mean weight loss. True.

1332
01:15:07.080 --> 01:15:14.290
If everyone in America who qualified for a GOP One analog got

1333
01:15:14.290 --> 01:15:17.640
it, that would be $2.1 trillion

1334
01:15:17.880 --> 01:15:20.540
dollars to the health care system, which is currently $4.1

1335
01:15:20.540 --> 01:15:24.040
trillion. So that would be a 50% surcharge over what we're

1336
01:15:24.040 --> 01:15:26.880
currently paying. And Medicare is going to go broke by the year

1337
01:15:26.880 --> 01:15:32.180
2029. Anyway, without it. So you're going to put another 50% on

1338
01:15:32.180 --> 01:15:35.160
top of that. How the hell are you going to pay for that for a

1339
01:15:35.160 --> 01:15:42.670
16% weight loss? Conversely, if we just got added sugar out of

1340
01:15:42.670 --> 01:15:45.480
the diet, out of the American diet,

1341
01:15:45.480 --> 01:15:49.740
to the level of USDA guidelines of 12 teaspoons of added sugar

1342
01:15:49.740 --> 01:15:57.880
per day, no more, we could get a 29% weight loss and save $3.0

1343
01:15:57.880 --> 01:16:03.000
trillion. That's a $5.1 trillion swing for double the weight

1344
01:16:03.000 --> 01:16:06.360
loss and no side effects. Which one do you think is better?

1345
01:16:06.360 --> 01:16:13.000
Yeah. That's how I feel about it. There was a recent animal

1346
01:16:13.000 --> 01:16:15.160
research study that suggested that things like

1347
01:16:15.160 --> 01:16:20.460
as MPEC semi-glutides reduced cocaine self administration in

1348
01:16:20.460 --> 01:16:24.780
rats by roughly 30% during treatment and cut their drug seeking

1349
01:16:24.780 --> 01:16:29.810
behavior by 62% after a period of abstinence. Which speaks to

1350
01:16:29.810 --> 01:16:32.360
some of the things you're saying there about GOP ones is MPEC's

1351
01:16:32.360 --> 01:16:37.000
role in the reward pathways in the brain. So it's interesting.

1352
01:16:37.000 --> 01:16:39.830
It's interesting. But what is that saying? It's saying that if

1353
01:16:39.830 --> 01:16:43.320
you in these rats, if they were given these GOP one antagonists

1354
01:16:43.320 --> 01:16:43.560
, these

1355
01:16:43.560 --> 01:16:48.770
MPECs, these semi-glutides, they were less likely to be

1356
01:16:48.770 --> 01:16:54.680
addicted to things. Yeah. I mean, I mean, I say less likely to

1357
01:16:54.680 --> 01:16:55.400
be addicted. They're

1358
01:16:55.400 --> 01:16:59.790
already addicted. They're basically choosing not to continue to

1359
01:16:59.790 --> 01:17:02.440
consume. And again, we don't know if

1360
01:17:02.440 --> 01:17:06.180
they're addicted to their rats. But their behaviors suggest

1361
01:17:06.180 --> 01:17:09.000
that they're reducing the consumption of the

1362
01:17:09.000 --> 01:17:11.960
addictive substance. And what is suggesting? This means that

1363
01:17:11.960 --> 01:17:15.960
the GOP one is doing what? Well, number one,

1364
01:17:15.960 --> 01:17:20.200
maybe the reason that they're not consuming more is because

1365
01:17:20.200 --> 01:17:22.200
their stomachs aren't moving.

1366
01:17:22.200 --> 01:17:26.250
If your stomach's not moving, you don't want to take any more.

1367
01:17:26.250 --> 01:17:29.080
Do you? Maybe it's that. We don't know.

1368
01:17:29.080 --> 01:17:32.860
That's one possibility. There's no question that the nucleus of

1369
01:17:32.860 --> 01:17:35.240
Cummins has GOP one receptors.

1370
01:17:35.240 --> 01:17:37.980
The ventral-tag metal area has GOP one receptors. And I

1371
01:17:37.980 --> 01:17:40.760
actually gave a talk at the California

1372
01:17:40.760 --> 01:17:45.200
Society of Addiction Medicine on those MPECs. So we know what

1373
01:17:45.200 --> 01:17:48.040
the data show. We're still

1374
01:17:48.040 --> 01:17:51.880
researching this and trying to investigate and figure out what

1375
01:17:51.880 --> 01:17:54.440
it is. That also wouldn't explain

1376
01:17:54.440 --> 01:17:59.570
the alcohol stroke because alcohol's not food. It's liquid. So

1377
01:17:59.570 --> 01:18:01.160
it's a little different. And it

1378
01:18:01.160 --> 01:18:06.110
definitely reduces alcoholism, alcohol consumption. So there

1379
01:18:06.110 --> 01:18:07.560
does seem to be an effect.

1380
01:18:07.560 --> 01:18:10.750
Understanding what dopamine does from what you said earlier, it

1381
01:18:10.750 --> 01:18:12.040
would appear that then these

1382
01:18:12.040 --> 01:18:16.490
like GOP ones, these MPECs are dampening. Dope means release in

1383
01:18:16.490 --> 01:18:18.040
some way because the rats, when

1384
01:18:18.040 --> 01:18:21.690
you talk about motivation and dopamine, the rats are less

1385
01:18:21.690 --> 01:18:23.960
motivated to go and get more cocaine.

1386
01:18:23.960 --> 01:18:28.680
Right. And that very well may be a good thing. And for certain

1387
01:18:28.680 --> 01:18:30.920
people, I think we can absolutely

1388
01:18:31.160 --> 01:18:34.360
use that phenomenon to assist them.

1389
01:18:34.360 --> 01:18:37.550
Is that perhaps that will be a good way to help with drug

1390
01:18:37.550 --> 01:18:38.200
introduction?

1391
01:18:38.200 --> 01:18:40.520
Did that also mean that I become less motivated period?

1392
01:18:40.520 --> 01:18:43.880
Yes. That's not good. Yes. That's what I'm worried about.

1393
01:18:43.880 --> 01:18:48.200
Going back to Jenny and Dave. Jenny and Dave both have a little

1394
01:18:48.200 --> 01:18:49.400
bit of extra weight on them.

1395
01:18:49.400 --> 01:18:52.320
We've talked about really interestingly the whole idea that

1396
01:18:52.320 --> 01:18:53.960
serotonin connection, love,

1397
01:18:53.960 --> 01:18:59.080
plays in a tremendous role and stress. And so Jenny and Dave

1398
01:18:59.080 --> 01:19:00.840
now, they're going to be thinking about

1399
01:19:00.840 --> 01:19:04.200
their relationships and friendships and going to that run club

1400
01:19:04.200 --> 01:19:07.640
as a way to help them downstream with

1401
01:19:07.640 --> 01:19:10.210
addictions and other things they're struggling with. Is there

1402
01:19:10.210 --> 01:19:11.960
anything else that Jenny and Dave

1403
01:19:11.960 --> 01:19:15.550
who represent the typical American need to know to maybe shed

1404
01:19:15.550 --> 01:19:17.720
some of that body fat?

1405
01:19:17.720 --> 01:19:23.800
Number one, ultra-processed food is obesity.

1406
01:19:25.480 --> 01:19:31.630
Now, if Jenny and Dave are under stress, if Jenny and Dave are

1407
01:19:31.630 --> 01:19:33.240
under financial stress,

1408
01:19:33.240 --> 01:19:37.500
if Jenny and Dave are under time stress, it's going to be

1409
01:19:37.500 --> 01:19:39.800
really hard for them to turn away

1410
01:19:39.800 --> 01:19:46.120
from ultra-process food. So don't expect their weight to get

1411
01:19:46.120 --> 01:19:49.000
any better until they fix their diet.

1412
01:19:49.000 --> 01:19:52.780
The one thing I am very sure of is that if you keep eating the

1413
01:19:52.780 --> 01:19:55.720
same shit, don't expect anything good

1414
01:19:55.720 --> 01:19:59.610
to happen. But it's hard. It's very hard. Some practical types

1415
01:19:59.610 --> 01:20:01.560
of things. The first thing is

1416
01:20:01.560 --> 01:20:05.790
that when they go to the store, don't go hungry. Okay, love

1417
01:20:05.790 --> 01:20:07.240
that. That's the first one.

1418
01:20:07.240 --> 01:20:10.430
I need that mistake alone. The second thing, why let's give

1419
01:20:10.430 --> 01:20:11.240
some context there?

1420
01:20:11.240 --> 01:20:13.990
Oh, because if they're hungry, all bets are off. They're done.

1421
01:20:13.990 --> 01:20:15.800
Because they're more likely to reach

1422
01:20:15.800 --> 01:20:20.040
the bad stuff. Because the best stuff's calling to them. And by

1423
01:20:20.040 --> 01:20:21.800
the way, the best stuff's on the

1424
01:20:21.800 --> 01:20:25.850
end caps of each of the aisles of the grocery store. And in the

1425
01:20:25.850 --> 01:20:27.640
middle? In the middle, well,

1426
01:20:27.640 --> 01:20:32.440
any, if you've gone into the aisles, you've gone off the rails

1427
01:20:32.440 --> 01:20:33.880
because that's where the ultra-process

1428
01:20:33.880 --> 01:20:37.700
food is. It's a shop around the outside, which is where the

1429
01:20:37.700 --> 01:20:42.280
real food is. The fridges and the produce

1430
01:20:42.280 --> 01:20:47.630
and the meats and the dairy, okay? Not to say that there isn't,

1431
01:20:47.630 --> 01:20:50.040
you know, ultra-processed food and sugar

1432
01:20:50.040 --> 01:20:54.720
hiding in those places too. But if you've gone into the, you

1433
01:20:54.720 --> 01:20:57.320
know, standard, you know, aisles,

1434
01:20:57.320 --> 01:21:01.430
you know, that's where ultra-processed food is hiding. And, you

1435
01:21:01.430 --> 01:21:03.880
know, 73% of the items in the

1436
01:21:03.880 --> 01:21:08.780
American grocery store are poison. So if you go into the

1437
01:21:08.780 --> 01:21:11.800
grocery store, you already have a problem.

1438
01:21:12.520 --> 01:21:17.000
So the first one is don't go hungry. The second one is to stay

1439
01:21:17.000 --> 01:21:20.280
on the outside of the supermarket.

1440
01:21:20.280 --> 01:21:24.970
Yeah. Anything else for Jenny and Dave? And most importantly,

1441
01:21:24.970 --> 01:21:27.640
you know, I don't want them to have to

1442
01:21:27.640 --> 01:21:32.070
read food labels because that's kind of, you know, out of

1443
01:21:32.070 --> 01:21:35.720
bounds, okay? But they should basically,

1444
01:21:36.680 --> 01:21:41.030
if a food has a label, it's a warning label. That's how they

1445
01:21:41.030 --> 01:21:47.080
should look at it, okay? And if any food

1446
01:21:47.080 --> 01:21:51.190
has a sugar in the first three items, the first three

1447
01:21:51.190 --> 01:21:53.160
ingredients, it's dessert.

1448
01:21:53.160 --> 01:21:58.910
That's how they should look at it. So, you know, Chinese

1449
01:21:58.910 --> 01:22:02.440
chicken salad is dessert.

1450
01:22:02.440 --> 01:22:06.340
Actually, not the other day I looked at my friend was drinking

1451
01:22:06.340 --> 01:22:09.320
a can of Coca-Cola and I picked it up

1452
01:22:09.320 --> 01:22:12.140
and I thought, "I've not seen one of these in a while." And I

1453
01:22:12.140 --> 01:22:13.880
looked at the back of it and it said

1454
01:22:13.880 --> 01:22:18.530
the sugar quantity in it was something like 40% in that region.

1455
01:22:18.530 --> 01:22:21.560
It was 39 grams in a can. Yeah.

1456
01:22:21.560 --> 01:22:28.140
That's right. I say, so 40% of it is just sugar. Correct. And

1457
01:22:28.140 --> 01:22:31.160
people are just, there you go.

1458
01:22:31.960 --> 01:22:37.350
No, that's why we have a fatty liver disease pandemic and sugar

1459
01:22:37.350 --> 01:22:38.840
is fundamentally linked to things

1460
01:22:38.840 --> 01:22:42.560
like cancer as well, right? Yes, absolutely. And we know why

1461
01:22:42.560 --> 01:22:44.600
now. We know how, you know,

1462
01:22:44.600 --> 01:22:48.230
through what mechanisms? What are the mechanisms? Up for cancer

1463
01:22:48.230 --> 01:22:50.360
? Yeah. Okay. So, first of all,

1464
01:22:50.360 --> 01:22:53.050
in anything that makes insulin go up increases your risk for

1465
01:22:53.050 --> 01:22:54.600
cancer because insulin's a growth

1466
01:22:54.600 --> 01:22:58.230
factor. Okay. Secondly, because insulin causes mitochondrial

1467
01:22:58.230 --> 01:23:01.800
dysfunction. Okay. It increases

1468
01:23:01.800 --> 01:23:05.890
these other phenomena like, for instance, the pentose phosphate

1469
01:23:05.890 --> 01:23:06.760
shunt and the

1470
01:23:06.760 --> 01:23:11.430
Randall cycle and the doonova lipogenesis, which is what cancer

1471
01:23:11.430 --> 01:23:13.080
cells need to be able to

1472
01:23:13.080 --> 01:23:16.860
multiply and divide. Okay. So, it's basically feeding the

1473
01:23:16.860 --> 01:23:20.440
cancer. Number three, certain cancers,

1474
01:23:20.440 --> 01:23:24.030
particularly pancreatic cancer, have an enzyme in them called

1475
01:23:24.030 --> 01:23:26.440
transketolase. And what that can do

1476
01:23:26.440 --> 01:23:30.030
is that can take fructose and turn it into glucose in the

1477
01:23:30.030 --> 01:23:31.720
cancer cell only so that when you're

1478
01:23:31.720 --> 01:23:35.180
actually consuming sugar, you are feeding the cancer

1479
01:23:35.180 --> 01:23:38.760
specifically. Yet, what do we give cancer patients

1480
01:23:38.760 --> 01:23:41.850
in a sugar, which is like straight fructose? So, you are

1481
01:23:41.850 --> 01:23:43.480
actually feeding the cancer.

1482
01:23:43.480 --> 01:23:49.720
So, that's like ridiculous. Okay. In addition, because fructose

1483
01:23:49.720 --> 01:23:52.040
interferes with mitochondrial

1484
01:23:52.040 --> 01:23:56.620
function, okay, that sends a feedback mechanism to the rest of

1485
01:23:56.620 --> 01:24:01.000
the cell to divide. Because dividing

1486
01:24:01.000 --> 01:24:04.460
cells are in growth phase, they don't have mitochondria. That's

1487
01:24:04.460 --> 01:24:05.800
why cancer cells don't have

1488
01:24:05.800 --> 01:24:08.990
mitochondria. So, if fetal cells don't have mitochondria, anaer

1489
01:24:08.990 --> 01:24:10.840
obes don't have mitochondria,

1490
01:24:10.840 --> 01:24:14.720
they grow the fastest. You know, provided that the conditions

1491
01:24:14.720 --> 01:24:17.560
are right. So, bottom line,

1492
01:24:17.560 --> 01:24:19.850
anything that interferes with mitochondrial function puts you

1493
01:24:19.850 --> 01:24:20.680
at risk for cancer.

1494
01:24:20.680 --> 01:24:25.740
And what we see in cancer is growing. There's the incidence of

1495
01:24:25.740 --> 01:24:26.840
people getting cancer.

1496
01:24:26.840 --> 01:24:29.640
Is that's growing? Absolutely. And people getting cancer

1497
01:24:29.640 --> 01:24:31.080
earlier and earlier,

1498
01:24:31.080 --> 01:24:35.400
especially colorectal cancer. My God, the mean age of colorect

1499
01:24:35.400 --> 01:24:40.600
al cancer used to be 50 to 55. It is now,

1500
01:24:40.600 --> 01:24:44.190
we are seeing patients with colorectal cancer in their 30s and

1501
01:24:44.190 --> 01:24:45.160
early 40s.

1502
01:24:45.160 --> 01:24:50.600
This is why. Because of, because of, because of sugar, that's a

1503
01:24:50.600 --> 01:24:51.320
huge problem.

1504
01:24:51.320 --> 01:24:54.980
It is a huge problem. So, that's what I would suggest Dave and

1505
01:24:54.980 --> 01:24:56.040
Jenny do to start.

1506
01:24:56.600 --> 01:25:00.190
Okay? But ultimately, they have to get their sugar and ultra-

1507
01:25:00.190 --> 01:25:02.280
process food consumption under control.

1508
01:25:02.280 --> 01:25:07.080
And the question is, can they do it alone? Chances are, to be

1509
01:25:07.080 --> 01:25:08.920
honest with you, they probably can't.

1510
01:25:08.920 --> 01:25:12.970
And the reason is because they're sugar-addicted, and because

1511
01:25:12.970 --> 01:25:14.600
the food industry is basically

1512
01:25:14.600 --> 01:25:18.300
made it impossible for them to avoid. That's what we have to

1513
01:25:18.300 --> 01:25:21.640
fix. We have to allow them the

1514
01:25:21.640 --> 01:25:25.810
capability of being able to access real food. This is why I'm

1515
01:25:25.810 --> 01:25:27.640
so upset with what's going on with

1516
01:25:27.640 --> 01:25:30.440
this argument here in the United States over Snap. Are you

1517
01:25:30.440 --> 01:25:32.920
familiar with Snap? Snap is the

1518
01:25:32.920 --> 01:25:37.710
supplementary nutrition assistance program, SNAP. Also known as

1519
01:25:37.710 --> 01:25:40.280
food stamps. Okay?

1520
01:25:40.280 --> 01:25:44.440
I actually testified in front of Congress, in front of the

1521
01:25:44.440 --> 01:25:47.160
House Appropriations Committee last year,

1522
01:25:48.040 --> 01:25:57.960
to fix SNAP. Now, to get soda off SNAP, because soda is like

1523
01:25:57.960 --> 01:25:59.480
the worst thing. And it's also

1524
01:25:59.480 --> 01:26:03.230
the thing that most people use their SNAP dollars. You know,

1525
01:26:03.230 --> 01:26:06.440
their SNAP vouchers to purchase.

1526
01:26:06.440 --> 01:26:11.440
And it's killing people. And so, I don't think soda should be

1527
01:26:11.440 --> 01:26:13.400
on SNAP. And so, what I did was

1528
01:26:13.400 --> 01:26:17.740
I testified basically explaining the science in Congress. And I

1529
01:26:17.740 --> 01:26:19.560
said that what we need to do is

1530
01:26:19.560 --> 01:26:24.330
take the money by banning soda sales on SNAP. If people want to

1531
01:26:24.330 --> 01:26:26.600
spend their own money on soda,

1532
01:26:26.600 --> 01:26:30.680
that's their business. But we shouldn't be using a federal

1533
01:26:30.680 --> 01:26:33.800
government subsidy program to subsidize

1534
01:26:33.800 --> 01:26:38.390
their death. We should take the money that's saved from the

1535
01:26:38.390 --> 01:26:40.680
soda sales and utilize it to

1536
01:26:40.680 --> 01:26:46.340
improve the nutrition of those same people, you know, real

1537
01:26:46.340 --> 01:26:51.080
vegetables, dietary supplements, fiber,

1538
01:26:51.080 --> 01:26:55.130
water. Okay? Things that will be healthy for them. In other

1539
01:26:55.130 --> 01:26:56.920
words, divert the monies.

1540
01:26:56.920 --> 01:27:02.920
They didn't hear that. Republicans are trying to basically gut

1541
01:27:02.920 --> 01:27:04.600
SNAP. They're trying to get rid of it

1542
01:27:04.600 --> 01:27:09.020
as an entity entirely. And if they don't, they can't gut it.

1543
01:27:09.020 --> 01:27:11.480
They will basically make it so that they

1544
01:27:11.480 --> 01:27:15.550
take the soda away, which is good, except it's not going to

1545
01:27:15.550 --> 01:27:18.120
improve the rest of their nutrition,

1546
01:27:18.120 --> 01:27:22.170
because they're basically just going to take that money and rep

1547
01:27:22.170 --> 01:27:25.560
ock at it. So, how you,

1548
01:27:25.560 --> 01:27:30.950
you know, set these legislation agenda items up is super

1549
01:27:30.950 --> 01:27:33.240
important. And right now,

1550
01:27:33.240 --> 01:27:36.830
this government's not doing it. Just give me 15 seconds to

1551
01:27:36.830 --> 01:27:38.760
explain how you can build a viable

1552
01:27:38.760 --> 01:27:41.420
business online. The people I see winning in life don't have a

1553
01:27:41.420 --> 01:27:42.680
perfect plan. They just take

1554
01:27:42.680 --> 01:27:45.420
the first step and then the next and then they keep going. They

1555
01:27:45.420 --> 01:27:47.480
stay obsessed and they stay consistent

1556
01:27:47.480 --> 01:27:51.110
and stand store a platform I co-own and one of our sponsors is

1557
01:27:51.110 --> 01:27:53.080
the best first step to help turn

1558
01:27:53.080 --> 01:27:55.990
your knowledge into income. It only takes a couple of minutes

1559
01:27:55.990 --> 01:27:57.560
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1560
01:27:57.560 --> 01:28:01.040
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1561
01:28:01.040 --> 01:28:03.000
online. Without any tech headaches or

1562
01:28:03.000 --> 01:28:06.370
endless setup, thousands of entrepreneurs, creators and risk t

1563
01:28:06.370 --> 01:28:08.280
akers, you stand to take control of their

1564
01:28:08.280 --> 01:28:12.060
future, because Stan is for entrepreneurs for those willing to

1565
01:28:12.060 --> 01:28:14.280
put in the work and bet on themselves.

1566
01:28:14.280 --> 01:28:17.640
If you're ready to start building, join us launch your business

1567
01:28:17.640 --> 01:28:20.280
today with a free 14 day trial

1568
01:28:20.280 --> 01:28:25.970
at Steven Bartlett dot Stan dot store. The messages and emails

1569
01:28:25.970 --> 01:28:27.960
that you get from people that have

1570
01:28:27.960 --> 01:28:31.320
heard you on podcast or if read your books or senior work in

1571
01:28:31.320 --> 01:28:34.040
other places, what is the typical

1572
01:28:34.040 --> 01:28:36.610
question that those people asked? If you had to summarize the

1573
01:28:36.610 --> 01:28:39.080
question into one question,

1574
01:28:39.080 --> 01:28:45.320
what is it that people ask you the most? Is juice healthy?

1575
01:28:45.320 --> 01:28:50.200
Really, that's probably the most common

1576
01:28:50.200 --> 01:28:53.570
question. You say sugar is bad, but isn't juice healthy? Is

1577
01:28:53.570 --> 01:28:55.800
juice healthy? Juice is not healthy.

1578
01:28:55.800 --> 01:28:58.990
Fruit is healthy. So what's the difference between fruit and

1579
01:28:58.990 --> 01:29:00.040
juice? The fiber.

1580
01:29:00.040 --> 01:29:06.360
Okay, fruit has fiber. The fiber reduces the rate of absorption

1581
01:29:06.360 --> 01:29:07.880
from the gut into the bloodstream.

1582
01:29:07.880 --> 01:29:12.450
And in doing so, you reduce the insulin response, you reduce

1583
01:29:12.450 --> 01:29:15.720
the glucose response. You basically

1584
01:29:15.720 --> 01:29:20.490
protect the liver. And because you've prevented its early

1585
01:29:20.490 --> 01:29:22.760
absorption, it goes further down the

1586
01:29:22.760 --> 01:29:25.700
intestine, where the microbiome can chew it up for its own

1587
01:29:25.700 --> 01:29:27.400
purposes, thus feeding the gut,

1588
01:29:27.400 --> 01:29:31.480
and generating short chain fatty acids, which are there for a

1589
01:29:31.480 --> 01:29:32.840
metabolically beneficial,

1590
01:29:32.840 --> 01:29:36.740
anti-inflammatory, anti Alzheimer's. Okay, and the fiber acts

1591
01:29:36.740 --> 01:29:38.680
like little scrubbies on the inside

1592
01:29:38.680 --> 01:29:41.870
of the colon to get rid of colon cancer cells. So you get all

1593
01:29:41.870 --> 01:29:44.680
sorts of benefits from the fiber

1594
01:29:44.680 --> 01:29:47.870
in the fruit. But as soon as you juice it, you've thrown the

1595
01:29:47.870 --> 01:29:50.360
fiber in the garbage. And so

1596
01:29:50.360 --> 01:29:54.420
well, you now have a sugar water. So eat the fruit. Don't drink

1597
01:29:54.420 --> 01:29:56.120
the juice. Problem is,

1598
01:29:56.120 --> 01:29:59.800
that's, you know, what that's not what the food industry's

1599
01:29:59.800 --> 01:30:00.600
selling.

1600
01:30:00.600 --> 01:30:03.860
What if I put the fruit in a blender and then instead of

1601
01:30:03.860 --> 01:30:05.320
throwing out the gunk,

1602
01:30:05.320 --> 01:30:09.080
I keep all the little bits in there? So what happens is that

1603
01:30:09.080 --> 01:30:10.600
the blades in the

1604
01:30:10.600 --> 01:30:13.790
revel or the Vitamix or the Nutribuliter, you know, whatever

1605
01:30:13.790 --> 01:30:15.640
you use to make your smoothie,

1606
01:30:15.640 --> 01:30:20.620
those blades are shearing that fiber into smithereens, into

1607
01:30:20.620 --> 01:30:22.520
such short pieces

1608
01:30:22.520 --> 01:30:28.240
that it can't actually act as a lattice work to sequester and

1609
01:30:28.240 --> 01:30:29.880
prevent that absorption.

1610
01:30:29.880 --> 01:30:34.220
So the rate of absorption in the intestine is just as fast, and

1611
01:30:34.220 --> 01:30:35.720
so the fructose and the glucose

1612
01:30:35.720 --> 01:30:39.570
will still get to the liver just as fast as it did before when

1613
01:30:39.570 --> 01:30:42.120
it was juice. So that's not

1614
01:30:42.120 --> 01:30:46.760
the answer. So making a smoothie out of it is not the answer. I

1615
01:30:46.760 --> 01:30:48.120
was looking at the top comments from

1616
01:30:48.120 --> 01:30:52.550
my last conversation and they're all extremely, that's a

1617
01:30:52.550 --> 01:30:55.080
similar, but they're all incredibly

1618
01:30:55.080 --> 01:30:58.360
inspiring. Someone here is written the top comment, which I

1619
01:30:58.360 --> 01:30:59.720
shall pre I shall record the screen

1620
01:30:59.720 --> 01:31:02.390
so Jack can throw it on the screen. So Stephen, I discovered

1621
01:31:02.390 --> 01:31:04.440
Robert three years ago after my

1622
01:31:04.440 --> 01:31:07.210
doctor told me I was pre diabetic three years on my blood

1623
01:31:07.210 --> 01:31:08.840
levels are completely normal and

1624
01:31:08.840 --> 01:31:12.260
everyone tells me how good I look recently. This man should be

1625
01:31:12.260 --> 01:31:13.560
on every TV in the world,

1626
01:31:13.560 --> 01:31:16.890
but the food industry is trying to shut him up. Follow the work

1627
01:31:16.890 --> 01:31:19.480
and you will change your life

1628
01:31:19.480 --> 01:31:24.470
like he changed mine. Stuart Jay, 59 years old, male in the UK.

1629
01:31:24.470 --> 01:31:25.640
That's very heartening. I'm glad

1630
01:31:25.640 --> 01:31:29.470
to hear that. Good for you Stuart. My friend was diagnosed with

1631
01:31:29.470 --> 01:31:31.960
stage four prostate cancer and given

1632
01:31:31.960 --> 01:31:36.060
one year to live. And he found Dr. Lustig and rigorously

1633
01:31:36.060 --> 01:31:38.600
followed his advice. Keto diet, it's

1634
01:31:38.600 --> 01:31:41.790
missing fasting, regular walking. That was two years ago. He's

1635
01:31:41.790 --> 01:31:43.640
now in remission. The cancer is gone.

1636
01:31:43.640 --> 01:31:50.110
I was diagnosed with pre diabetes, fibro myalgia and decided to

1637
01:31:50.110 --> 01:31:52.120
cut out all the sugar including

1638
01:31:52.120 --> 01:31:55.870
fruit. Not only do I lose 60 pounds in under a year, but my

1639
01:31:55.870 --> 01:31:59.000
pain went from 10 to 1 to 2. I had more

1640
01:31:59.000 --> 01:32:03.900
energy. My A1C dropped to normal levels and I went from being

1641
01:32:03.900 --> 01:32:06.040
fully disabled to going back to work

1642
01:32:06.040 --> 01:32:09.830
full-time, cutting out all the sugar is hard. I won't lie. It's

1643
01:32:09.830 --> 01:32:12.040
also a constant, constant battle,

1644
01:32:12.040 --> 01:32:18.920
but it is so worth it. And lastly, I listened to this podcast

1645
01:32:18.920 --> 01:32:21.800
last year. I made a decision on December

1646
01:32:21.800 --> 01:32:25.890
28th, 2023 to stay away from all candy brownies, maple walnut

1647
01:32:25.890 --> 01:32:27.800
scones and all desserts. You get

1648
01:32:27.800 --> 01:32:32.350
the idea. It is now approaching December 28th, 2024. And

1649
01:32:32.350 --> 01:32:35.080
besides rewatching this video, I have made

1650
01:32:35.080 --> 01:32:38.670
another commitment to do the same thing I did last year. It's a

1651
01:32:38.670 --> 01:32:40.920
shame that 73% of what's in the

1652
01:32:40.920 --> 01:32:43.830
isles in the grocery store have hidden sugar in it. And so I

1653
01:32:43.830 --> 01:32:47.160
haven't gotten radical about it,

1654
01:32:47.160 --> 01:32:51.930
but the changes I've made have made me feel terrific. Dr.

1655
01:32:51.930 --> 01:32:55.080
Robert is the cat's meow,

1656
01:32:56.120 --> 01:33:00.800
and he has a giant part of in me getting me back, purring. I'm

1657
01:33:00.800 --> 01:33:03.800
68 and play five days a week,

1658
01:33:03.800 --> 01:33:08.800
two to four hours a day pickleball. I love the choices I've

1659
01:33:08.800 --> 01:33:10.680
made. I love you, Dr.

1660
01:33:10.680 --> 01:33:16.840
You know what? I love you too. And I'm 68.

1661
01:33:20.200 --> 01:33:25.590
Maybe when I go to the UK, we'll have a date. Well, that's

1662
01:33:25.590 --> 01:33:27.720
lovely. She's quite a pretty

1663
01:33:27.720 --> 01:33:34.940
Oh, very nice. How does that make you feel? Very heartened. I

1664
01:33:34.940 --> 01:33:37.240
can see the emotion in your face.

1665
01:33:37.240 --> 01:33:42.630
Yes, very heartened, but the problem is not fixed. The problem

1666
01:33:42.630 --> 01:33:44.360
is fixed for each of these people,

1667
01:33:44.360 --> 01:33:47.550
but the problem's not fixed. And because the problem's not

1668
01:33:47.550 --> 01:33:50.600
fixed, I still have a job to do.

1669
01:33:50.600 --> 01:33:56.900
So it gives me more strength to do it. It gives me more purpose

1670
01:33:56.900 --> 01:33:59.080
and gives me more reason to do it,

1671
01:33:59.080 --> 01:34:03.710
but you know, the problem's not fixed. Do you think one of the

1672
01:34:03.710 --> 01:34:04.920
most impactful

1673
01:34:04.920 --> 01:34:07.830
things that we could all do for our health is just to reduce

1674
01:34:07.830 --> 01:34:09.160
our sugar consumption?

1675
01:34:09.720 --> 01:34:14.780
I mean, that's that's job one. Okay. There are many things, but

1676
01:34:14.780 --> 01:34:17.560
without question, that's the easiest one.

1677
01:34:17.560 --> 01:34:20.930
And to be honest with you, the food industry should be helping

1678
01:34:20.930 --> 01:34:21.720
us do that.

1679
01:34:21.720 --> 01:34:24.810
The only reason the sugars in the food is because they wanted

1680
01:34:24.810 --> 01:34:26.680
it there. They put it there on

1681
01:34:26.680 --> 01:34:29.870
purpose because they knew when they added you by more. And

1682
01:34:29.870 --> 01:34:33.080
exercise, how does that impact my

1683
01:34:33.080 --> 01:34:37.130
decision to reach for sugar or not reach for sugar? Well, it

1684
01:34:37.130 --> 01:34:38.600
doesn't really impact your

1685
01:34:38.600 --> 01:34:43.670
desire to reach for sugar. It has its own metabolic benefits. I

1686
01:34:43.670 --> 01:34:45.720
'm totally for exercise. Don't

1687
01:34:45.720 --> 01:34:50.200
get me wrong. I am completely for exercise. Exercise does many

1688
01:34:50.200 --> 01:34:52.680
good things, but burning calories is

1689
01:34:52.680 --> 01:34:57.740
not one of them. Okay. People think, oh, you know, exercise to

1690
01:34:57.740 --> 01:35:00.520
work off the doughnut that I ate.

1691
01:35:00.520 --> 01:35:04.920
Wrong. Forget it. That's not what it's about. What does

1692
01:35:04.920 --> 01:35:07.160
exercise do? Exercise increases

1693
01:35:07.160 --> 01:35:10.370
mitochondria. And that's good because you need increased

1694
01:35:10.370 --> 01:35:13.240
mitochondrial reserve in order to make all that ATP.

1695
01:35:13.240 --> 01:35:18.150
Exercise increases brain trophic factors which are necessary

1696
01:35:18.150 --> 01:35:20.040
for cognition. And it's been shown

1697
01:35:20.040 --> 01:35:24.970
now that exercise is one of the primary methods for mitigating

1698
01:35:24.970 --> 01:35:28.440
risk for dementia. Okay. It increases

1699
01:35:28.440 --> 01:35:31.870
brain-derived neurotrophic factor. It increases leptin. All of

1700
01:35:31.870 --> 01:35:33.880
these are necessary to promote

1701
01:35:33.880 --> 01:35:38.360
synaptogenesis and even increase neurogenesis more neurons, you

1702
01:35:38.360 --> 01:35:40.360
know, so that they don't die.

1703
01:35:40.360 --> 01:35:46.200
So I'm all for exercise. Exercise also increases muscle mass.

1704
01:35:46.200 --> 01:35:50.840
And muscle mass is mitigating factor

1705
01:35:50.840 --> 01:35:54.700
for early demise. Like I said, sarcopenia is a risk factor for

1706
01:35:54.700 --> 01:35:57.480
early demise. So exercise is the way

1707
01:35:57.480 --> 01:36:00.980
to undo that. Having said that, none of that had anything to do

1708
01:36:00.980 --> 01:36:04.440
with weight loss. Okay. So if you think

1709
01:36:04.440 --> 01:36:10.740
exercise is going to make you lose weight, you are deluded. You

1710
01:36:10.740 --> 01:36:14.600
are under a delusion. You have adopted

1711
01:36:14.600 --> 01:36:19.420
the calorie hypothesis. I am here to dispel. I am here to

1712
01:36:19.420 --> 01:36:22.440
destroy the calorie hypothesis.

1713
01:36:22.440 --> 01:36:26.330
A calorie is not a calorie. So many of the people that are

1714
01:36:26.330 --> 01:36:28.360
listening to this conversation right now.

1715
01:36:28.360 --> 01:36:30.810
If they're in the United States or if they're in other parts of

1716
01:36:30.810 --> 01:36:32.200
the world that have similar health

1717
01:36:32.200 --> 01:36:38.600
stats are diabetic or pre-diabetic. One in 10 people worldwide

1718
01:36:38.600 --> 01:36:40.200
have diabetes and in the United

1719
01:36:40.200 --> 01:36:44.490
States, one in three to four of adults that are listening right

1720
01:36:44.490 --> 01:36:47.880
now are pre-diabetic. Even if you

1721
01:36:47.880 --> 01:36:50.560
don't have a huge amount of fat on your body, you can actually

1722
01:36:50.560 --> 01:36:52.680
40% four out of 10, which is crazy.

1723
01:36:52.680 --> 01:36:57.640
Yeah. That's right. It means that almost half of the people

1724
01:36:57.640 --> 01:36:58.680
listening right now, whether you

1725
01:36:58.680 --> 01:37:02.480
know it or not, could well be pre-diabetic if you fit into the

1726
01:37:02.480 --> 01:37:04.280
statistics that we have here.

1727
01:37:04.280 --> 01:37:13.310
I mean, terrifying. Oh yeah. So for this people that are pre-di

1728
01:37:13.310 --> 01:37:14.440
abetic, that I've just found

1729
01:37:14.440 --> 01:37:17.210
because I asked this question because there is a guy here that

1730
01:37:17.210 --> 01:37:20.280
says his doctor has just told him

1731
01:37:20.280 --> 01:37:23.240
he's pre-diabetic and he's listening to the show probably again

1732
01:37:23.240 --> 01:37:25.000
. So I wanted to offer him

1733
01:37:25.000 --> 01:37:27.580
something. His doctor has just told him that he's pre-diabetic.

1734
01:37:27.580 --> 01:37:29.720
What should he be doing?

1735
01:37:29.720 --> 01:37:33.420
Right. First thing, get rid of ultra-processed food from your

1736
01:37:33.420 --> 01:37:36.120
diet and in the process,

1737
01:37:36.120 --> 01:37:38.340
you will have gotten rid of all the sugar from your diet. That

1738
01:37:38.340 --> 01:37:41.320
's the first thing. See how that works.

1739
01:37:42.840 --> 01:37:49.920
Okay. Spend two weeks doing just that. If that works, fantastic

1740
01:37:49.920 --> 01:37:51.480
. If that doesn't work,

1741
01:37:51.480 --> 01:37:56.840
add some exercise. Walk. Walk your dog.

1742
01:37:56.840 --> 01:38:00.550
Okay. So on the first point, should he be using a glucose

1743
01:38:00.550 --> 01:38:03.000
monitor to help him? Because people can

1744
01:38:03.000 --> 01:38:05.790
get on Amazon or these are the websites. Very, you know, $20, $

1745
01:38:05.790 --> 01:38:07.720
30 you can get a glucose monitor

1746
01:38:07.720 --> 01:38:11.520
for your own. Yeah. So I am four glucose monitors. And the

1747
01:38:11.520 --> 01:38:14.120
reason is because they are a substitute,

1748
01:38:14.120 --> 01:38:17.590
a proxy for insulin. When the glucose goes up, that means the

1749
01:38:17.590 --> 01:38:19.720
insulin goes up. And it's the

1750
01:38:19.720 --> 01:38:23.450
insulin that really makes the difference. So we have

1751
01:38:23.450 --> 01:38:27.000
documentation of the fact that by monitoring

1752
01:38:27.000 --> 01:38:32.280
your own glucose concentration, you can see improvements in

1753
01:38:32.280 --> 01:38:34.520
metabolic health down the line.

1754
01:38:35.240 --> 01:38:39.540
You can foodlog. You can use the glucose monitoring. You don't

1755
01:38:39.540 --> 01:38:41.320
need to do glucose monitoring. You can

1756
01:38:41.320 --> 01:38:45.030
just do it with the food logging and it will still work. Bottom

1757
01:38:45.030 --> 01:38:46.760
line, there are a whole bunch

1758
01:38:46.760 --> 01:38:50.810
of scientists who are against using glucose monitors for non-di

1759
01:38:50.810 --> 01:38:52.840
abetics. And they write about this

1760
01:38:52.840 --> 01:38:56.040
routinely. They seem to write about it always in the New York

1761
01:38:56.040 --> 01:39:00.440
Times. I am completely 180 degrees

1762
01:39:00.440 --> 01:39:03.930
opposite on that. I think it is a very good idea. The reason

1763
01:39:03.930 --> 01:39:06.600
that they say it is a bad idea is because

1764
01:39:06.600 --> 01:39:11.450
if you're using the same outcome variables as for diabetes,

1765
01:39:11.450 --> 01:39:14.200
time in range, time above range, time

1766
01:39:14.200 --> 01:39:17.500
below range, well, these are non-diabetics. So of course, all

1767
01:39:17.500 --> 01:39:19.560
of those numbers are going to be in

1768
01:39:19.560 --> 01:39:22.160
the center. They're going to be in the time in range. So it

1769
01:39:22.160 --> 01:39:23.960
looks like there's no benefit to that.

1770
01:39:25.320 --> 01:39:29.770
That's not the point. The point is the downstream outcomes

1771
01:39:29.770 --> 01:39:32.040
which come three months later,

1772
01:39:32.040 --> 01:39:35.510
they're not looking at that. We have those data. We are looking

1773
01:39:35.510 --> 01:39:37.400
at that and the data are very good.

1774
01:39:37.400 --> 01:39:40.890
Do you know Joe and I think is really, really useful with those

1775
01:39:40.890 --> 01:39:42.120
CGMs, those continuous glucose

1776
01:39:42.120 --> 01:39:45.900
monitors that you can buy online super cheaply? Is they just

1777
01:39:45.900 --> 01:39:48.760
educate you on the impact that

1778
01:39:48.760 --> 01:39:51.210
different foods you might have thought were healthy? Like the

1779
01:39:51.210 --> 01:39:53.000
juices we talked about? Like rice?

1780
01:39:53.000 --> 01:39:56.200
Yeah. Like rice. That's actually one of the big things I don't

1781
01:39:56.200 --> 01:39:57.240
do. There's two things that

1782
01:39:57.240 --> 01:39:59.150
shock me. Three things that have shocked me over the last

1783
01:39:59.150 --> 01:40:01.000
couple of years that I thought were healthy.

1784
01:40:01.000 --> 01:40:03.790
So I grew up thinking that orange juices were healthy. I

1785
01:40:03.790 --> 01:40:05.560
remember being a young kid and getting

1786
01:40:05.560 --> 01:40:09.180
the sunny delight out of the fridge and like glugging it

1787
01:40:09.180 --> 01:40:11.160
because I had seen on the advert,

1788
01:40:11.160 --> 01:40:14.350
it said vitamin C or something. And I thought, oh, vitamin C,

1789
01:40:14.350 --> 01:40:17.000
good, glug it. I've come to learn.

1790
01:40:17.000 --> 01:40:22.660
That was their subterfuge and you were a victim. I was a victim

1791
01:40:22.660 --> 01:40:24.280
and I would like compensation.

1792
01:40:24.280 --> 01:40:31.280
Sunny day. I think the entire UK population, the US population

1793
01:40:31.280 --> 01:40:32.680
deserves compensation.

1794
01:40:32.680 --> 01:40:35.330
There's a young lady in the comments section who watched our

1795
01:40:35.330 --> 01:40:36.600
conversation last time.

1796
01:40:36.600 --> 01:40:40.190
She said, "A quote from this doctor that I loved and I've never

1797
01:40:40.190 --> 01:40:42.360
forgotten is any food

1798
01:40:42.360 --> 01:40:45.600
that is linked to a television commercial should not be

1799
01:40:45.600 --> 01:40:48.120
consumed brilliantly sad and a great

1800
01:40:48.120 --> 01:40:52.210
boundary to put in place." Yep, that's right. Any food that is

1801
01:40:52.210 --> 01:40:53.400
linked to a television commercial

1802
01:40:53.400 --> 01:40:56.040
should not be consumed. It's so true. They don't put cucumbers

1803
01:40:56.040 --> 01:40:57.640
in television commercials. Nope.

1804
01:40:57.640 --> 01:41:07.260
Not enough marketing money. Not enough margin. So Sunny day

1805
01:41:07.260 --> 01:41:07.960
that's orange juices,

1806
01:41:07.960 --> 01:41:10.730
generally, I don't drink any juices anymore. I haven't for

1807
01:41:10.730 --> 01:41:11.400
years now.

1808
01:41:11.400 --> 01:41:13.620
The other one was white rice. I thought that was healthy

1809
01:41:13.620 --> 01:41:15.080
growing up. That was really, really healthy.

1810
01:41:15.080 --> 01:41:17.440
And then I did a continuous glucose monitor with a company that

1811
01:41:17.440 --> 01:41:18.360
I'm an investor in called

1812
01:41:18.360 --> 01:41:24.030
Vizzoui. And it gave me this. It was like, it was horrific. The

1813
01:41:24.030 --> 01:41:25.720
impact on my gut microbiome

1814
01:41:25.720 --> 01:41:29.770
and my glucose levels. And the third one was tomato ketchup. I

1815
01:41:29.770 --> 01:41:31.400
didn't know there was so much

1816
01:41:31.400 --> 01:41:37.340
bloody sugar in most ketchup. In fact, Heinz ketchup has high

1817
01:41:37.340 --> 01:41:38.840
fructose corn syrup.

1818
01:41:39.560 --> 01:41:42.830
Madness. And that's the value of getting a continuous glucose

1819
01:41:42.830 --> 01:41:44.440
monitor. Even if you just run it for

1820
01:41:44.440 --> 01:41:48.180
14 days, is you'll learn your relationship with these things

1821
01:41:48.180 --> 01:41:49.640
you frequently eat. And most

1822
01:41:49.640 --> 01:41:52.210
of us are frequent eaters. We eat the same kind of things. And

1823
01:41:52.210 --> 01:41:55.160
you can make some trades.

1824
01:41:55.160 --> 01:41:56.930
What is the most important thing we haven't talked about that

1825
01:41:56.930 --> 01:41:58.520
we should have talked about, Robert?

1826
01:41:58.520 --> 01:42:04.180
I know what we haven't talked about. Psychedelics. What would

1827
01:42:04.180 --> 01:42:06.440
you like to talk about with psychedelics?

1828
01:42:07.560 --> 01:42:13.560
Psychedelics are serotonin. A big dose. A big glug of serotonin

1829
01:42:13.560 --> 01:42:14.520
. I don't know what once.

1830
01:42:14.520 --> 01:42:21.390
What serotonin does is it provides you with this sense of compl

1831
01:42:21.390 --> 01:42:22.520
acency of

1832
01:42:22.520 --> 01:42:27.890
eutomonia, of contentment. Serotonin is necessary to rewire

1833
01:42:27.890 --> 01:42:30.200
areas of the brain.

1834
01:42:30.200 --> 01:42:35.100
You can actually see it on MRI. So actually leading to synaptic

1835
01:42:35.100 --> 01:42:37.160
rewiring. Think of it this way.

1836
01:42:37.640 --> 01:42:40.370
I just can't find that just on the point. You're not saying

1837
01:42:40.370 --> 01:42:42.680
that psychedelics create serotonin.

1838
01:42:42.680 --> 01:42:46.460
You're saying that they are the same. They are serotonin mimic

1839
01:42:46.460 --> 01:42:48.360
or. They mimic serotonin.

1840
01:42:48.360 --> 01:42:56.460
Think of it this way. You live on a mountain with snow. And you

1841
01:42:56.460 --> 01:42:59.960
have to every week go down to

1842
01:42:59.960 --> 01:43:04.560
the general store at the base of the mountain. And you ski down

1843
01:43:04.560 --> 01:43:07.160
there. And you ski down there.

1844
01:43:07.160 --> 01:43:11.450
And the snow falls and you ski down there. And soon what you've

1845
01:43:11.450 --> 01:43:15.080
done is you've created ridges in the snow

1846
01:43:15.080 --> 01:43:22.080
for you to get down the hill. And they freeze. And soon the

1847
01:43:22.080 --> 01:43:24.600
only way to get down the hill

1848
01:43:24.600 --> 01:43:29.280
is through the ridges that you've created. You are now

1849
01:43:29.280 --> 01:43:32.680
basically in a rut. You have trapped

1850
01:43:32.680 --> 01:43:37.480
into that path. There's no other way out your house. Other than

1851
01:43:37.480 --> 01:43:41.320
those ridges that have frozen

1852
01:43:41.320 --> 01:43:47.080
in place. That's what's happening in your brain. You can't un

1853
01:43:47.080 --> 01:43:50.040
think your way out of it because

1854
01:43:50.040 --> 01:43:52.040
that's the only way you know.

1855
01:43:55.240 --> 01:44:01.550
psychedelics are like a huge enormous blizzard filling in the r

1856
01:44:01.550 --> 01:44:03.160
uts filling in the ridges.

1857
01:44:03.160 --> 01:44:08.100
So you end up with a pristine, you know, snowbank for you to be

1858
01:44:08.100 --> 01:44:10.520
able to basically ski any

1859
01:44:10.520 --> 01:44:16.690
which way you want. It's your way out of your rut. And what we

1860
01:44:16.690 --> 01:44:19.400
have in America and UK too

1861
01:44:20.440 --> 01:44:23.670
is a whole lot of people with set of belief systems that have

1862
01:44:23.670 --> 01:44:26.040
put them into ruts that they can't

1863
01:44:26.040 --> 01:44:30.090
think their way out of. Now, can this be done without psychedel

1864
01:44:30.090 --> 01:44:32.760
ics? Absolutely. But it's hard.

1865
01:44:32.760 --> 01:44:41.400
psychedelics are a way to shall we say hack that belief system

1866
01:44:41.400 --> 01:44:43.880
concept and allow you to rethink

1867
01:44:44.520 --> 01:44:48.880
your own life and the life of the people around you and how you

1868
01:44:48.880 --> 01:44:51.480
interact with them. And

1869
01:44:51.480 --> 01:44:59.560
we need more research in this to solve mental illness and also

1870
01:44:59.560 --> 01:45:04.280
improve the well-being of

1871
01:45:04.280 --> 01:45:07.480
sizeable portion of the population.

1872
01:45:07.480 --> 01:45:10.520
I'm a big fan of the research taking place with

1873
01:45:11.480 --> 01:45:14.670
into the psychedelic field. I actually spent a year of my life

1874
01:45:14.670 --> 01:45:17.160
in what I believe is the biggest

1875
01:45:17.160 --> 01:45:20.590
psychedelics company in the world as an investor. And then as a

1876
01:45:20.590 --> 01:45:23.640
director in a capacity where I was

1877
01:45:23.640 --> 01:45:28.120
helping to drive fundraising through marketing and then the

1878
01:45:28.120 --> 01:45:30.040
company is now a public business that's

1879
01:45:30.040 --> 01:45:32.790
doing a lot of the clinical studies. So which way is it? It's a

1880
01:45:32.790 --> 01:45:35.080
tie-life sciences. I obviously

1881
01:45:35.080 --> 01:45:37.880
compass pathways as well. I'm an investor in that company and a

1882
01:45:37.880 --> 01:45:40.440
big fan of what maps are doing

1883
01:45:40.440 --> 01:45:43.630
as it relates to using these molecules for mental health

1884
01:45:43.630 --> 01:45:45.480
disorders and treatment-resistant

1885
01:45:45.480 --> 01:45:49.160
depression, PTSD, anxiety, etc. And it's so shocking to me that

1886
01:45:49.160 --> 01:45:52.760
it's taken so long to

1887
01:45:52.760 --> 01:45:58.020
well, they got a bad rap from Nixon back in the 1970s and I

1888
01:45:58.020 --> 01:46:00.200
understand why. By the way,

1889
01:46:00.200 --> 01:46:04.360
no one should do psychedelics alone. You do them with a guide,

1890
01:46:04.360 --> 01:46:06.200
you do them with someone you

1891
01:46:06.200 --> 01:46:13.280
completely trust, where safety is paramount, and they can be

1892
01:46:13.280 --> 01:46:14.760
really remarkable.

1893
01:46:14.760 --> 01:46:17.950
And we talk about sets and setting, which is hopefully they'll

1894
01:46:17.950 --> 01:46:19.000
be done in clinical settings

1895
01:46:19.000 --> 01:46:22.190
with, as you say, with a practitioner. Yes, that's the only way

1896
01:46:22.190 --> 01:46:23.160
they should be done.

1897
01:46:23.160 --> 01:46:25.480
Dr. Robert, we have a closing tradition on this podcast where

1898
01:46:25.480 --> 01:46:26.440
the last guest leaves a question

1899
01:46:26.440 --> 01:46:28.670
for the next not knowing who they're leaving it for. I knew it

1900
01:46:28.670 --> 01:46:30.040
was coming. Yes, he did.

1901
01:46:30.840 --> 01:46:35.050
Looking at your life and the lives of others, how would you

1902
01:46:35.050 --> 01:46:37.000
describe the journey of life

1903
01:46:37.000 --> 01:46:39.000
and how to approach it?

1904
01:46:39.000 --> 01:46:46.520
When you come out of the box, when you're born,

1905
01:46:50.280 --> 01:46:58.280
you already have neurons and synapses and neural pathways that

1906
01:46:58.280 --> 01:47:00.360
have developed, even though

1907
01:47:00.360 --> 01:47:06.960
you've had no experience. The experience will either solidify

1908
01:47:06.960 --> 01:47:09.240
those or destroy them.

1909
01:47:09.240 --> 01:47:14.360
Ultimately, those turn into belief systems.

1910
01:47:17.640 --> 01:47:21.400
Almost every belief system that you thought you understood

1911
01:47:21.400 --> 01:47:23.880
about how the world works

1912
01:47:23.880 --> 01:47:33.720
is wrong. You have to be open to the fact that all the things

1913
01:47:33.720 --> 01:47:35.080
you thought were true

1914
01:47:35.080 --> 01:47:42.080
aren't. And if you are that open with yourself, you will know

1915
01:47:42.080 --> 01:47:43.480
yourself, and if you know yourself,

1916
01:47:44.520 --> 01:47:51.240
you can be happy. But if you believe your belief systems and

1917
01:47:51.240 --> 01:47:52.840
you've never questioned them,

1918
01:47:52.840 --> 01:47:58.680
you're never going to get there. Amen.

1919
01:47:58.680 --> 01:48:03.880
Robert, thank you so much. I mean, I say to some people

1920
01:48:03.880 --> 01:48:04.920
sometimes at the end of these podcasts

1921
01:48:04.920 --> 01:48:06.520
that they're doing good in the world, but you're quite frankly

1922
01:48:06.520 --> 01:48:07.480
saving a lot of people's lives.

1923
01:48:07.480 --> 01:48:10.050
I mean, the fact that all the top comments and the videos seem

1924
01:48:10.050 --> 01:48:11.720
to be dominated by the same narrative

1925
01:48:11.720 --> 01:48:14.190
that you've saved someone's life, you've improved their life is

1926
01:48:14.190 --> 01:48:16.600
. I mean, is there any higher work one

1927
01:48:16.600 --> 01:48:20.390
can do with their life than improve the quality and duration

1928
01:48:20.390 --> 01:48:22.440
and health of someone else's life?

1929
01:48:22.440 --> 01:48:24.370
And that's exactly what you're doing. It's what you've done

1930
01:48:24.370 --> 01:48:25.960
through your public advocacy work.

1931
01:48:25.960 --> 01:48:29.310
I know you recently spent some time with Prince Charles in the

1932
01:48:29.310 --> 01:48:30.840
UK, which is incredibly exciting.

1933
01:48:30.840 --> 01:48:34.720
The King of England talking to him about health outcomes and

1934
01:48:34.720 --> 01:48:36.360
all of the work that you've been doing.

1935
01:48:36.360 --> 01:48:40.790
And it's what I'm wondering is to be invited by him to him

1936
01:48:40.790 --> 01:48:43.000
asking for your opinions and your

1937
01:48:43.000 --> 01:48:46.460
perspective on health, which is something that's quite close to

1938
01:48:46.460 --> 01:48:47.640
the heart of the King.

1939
01:48:47.640 --> 01:48:50.570
And then through these books, these incredible books that I

1940
01:48:50.570 --> 01:48:51.640
have in front of me here,

1941
01:48:51.640 --> 01:48:54.810
which I'm going to link all of them below. This one's a new,

1942
01:48:54.810 --> 01:48:56.040
right? So this one's coming

1943
01:48:56.040 --> 01:48:58.960
out of September 16th. Okay, so that'll be out by the time the

1944
01:48:58.960 --> 01:49:00.120
conversations I believe.

1945
01:49:00.120 --> 01:49:03.480
And these incredible books, I mean, there's so many of them

1946
01:49:03.480 --> 01:49:04.920
that I can't pick a favorite child,

1947
01:49:04.920 --> 01:49:08.180
but they're all incredible, depending on where people are at in

1948
01:49:08.180 --> 01:49:09.000
their lives and what they're

1949
01:49:09.000 --> 01:49:12.630
trying to understand. Robert, thank you so much. It's been my

1950
01:49:12.630 --> 01:49:13.560
pleasure.

1951
01:49:13.560 --> 01:49:17.720
Make sure you keep what I'm about to say to yourself, I'm

1952
01:49:17.720 --> 01:49:19.960
inviting 10,000 of you to come even

1953
01:49:19.960 --> 01:49:24.060
deeper into the dire of a CEO. Welcome to my inner circle. This

1954
01:49:24.060 --> 01:49:26.120
is a brand new private community

1955
01:49:26.120 --> 01:49:28.430
that I'm launching to the world. We have so many incredible

1956
01:49:28.430 --> 01:49:30.120
things that happen that you are

1957
01:49:30.120 --> 01:49:32.850
never shown. We have the briefs that are on my pad when I'm

1958
01:49:32.850 --> 01:49:34.440
recording the conversation.

1959
01:49:34.440 --> 01:49:37.190
We have clips we've never released. We have behind-the-scenes

1960
01:49:37.190 --> 01:49:38.760
conversations with the guests and also

1961
01:49:38.760 --> 01:49:43.470
the episodes that we've never ever released. And so much more.

1962
01:49:43.470 --> 01:49:45.560
In a circle, you'll have direct access

1963
01:49:45.560 --> 01:49:48.280
to me. You can tell us what you want this show to be, who you

1964
01:49:48.280 --> 01:49:49.800
want us to interview and the types

1965
01:49:49.800 --> 01:49:53.120
of conversations you would love us to have. But remember for

1966
01:49:53.120 --> 01:49:55.000
now, we're only inviting the first

1967
01:49:55.000 --> 01:49:58.190
10,000 people that join before it closes. So if you want to

1968
01:49:58.190 --> 01:49:59.480
join our private close community,

1969
01:49:59.480 --> 01:50:04.320
head to the link in the description below or go to DOACcircle.

1970
01:50:04.320 --> 01:50:09.480
com. I will speak to you then.

1971
01:50:29.480 --> 01:50:32.060
(upbeat music)